A "CAGA" sequence proximal to the "ATG" start codon was present in a location unique to APP genes of amyloid plaque-forming species and absent in all other genes surveyed. This CAGA box is immediately upstream of an interleukin-1-responsive element (acute box). In addition, the proximal ...
Smad-binding sequences, termed CAGA boxes, are present in the promoter of human PAI-1 gene, and they mediate TGF-β transcriptional induction. However, the functional role of each CAGA box in the Ox-LDL-induced PAI-1 promoter activation is unknown. In this study, mutation of 1 of the 3...
33.Asahi M, Tanaka Y, Izumi T, Ito Y, Naiki H, Kersulyte D, Tsujikawa K, Saito M, Sada K, Yanagi S. Helicobacter pylori CagA containing ITAM-like sequences localized to lipid rafts negatively regulates VacA-induced signaling in vivo.Helicobacter. 2003;8:1-14.[PubMed][DOI] ...
Arrows indicate EPIYA phosphorylation on AF202923; structural domains of CagA with corresponding amino acid sequence are denoted by rectangular boxes29. (b) The wt or mutant CagA expression vectors were co-transfected with a minimum amount of Snail (50 ng) and GFP (200 ng) expression vectors ...
coli. The DNA sequence encoding the N-terminal region (residues 1–220) of human SHP2 that contains two wild-type SH2 domains (SHP2/SH2) or functionally dead SH2 domains (SHP2/SH2D; where D means "dead") has been described previously9. The DNA fragment encoding full-length SHP2, ...
The CagA sequence was derived from the H. pylori strain G27, and CagA mutants were expressed in MDCK II cells as a model for polarized epithelial cells (25, 32, 33). All of the CagA constructs were tagged with GFP at the N terminus of CagA and transiently or stably expressed in a ...
No.30370078Correspondence to: Dr. Jian-Zhong Zhang, Department of Diagnosis,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention, PO Box 5, Beijing102206, China. helico@public.bta.net.cnReceived: 2004-02-14 Accepted: 2004-03-06Abstract...
carrying the various EPIYA constructs and thekan-sacBcassette was replaced via double homologous recombination. As controls, the entirecagAcoding sequence was replaced with akan-sacBcassette (ΔcagA), a truncated CagA protein was constructed with the addition of acatcassette (light blue box;cagA::...