品系描述 通过C57BL/6-Gt(ROSA)26Sortm1(CAG-LNL-Cas9)Smoc(NM-KI-00038)与EIIA-Cre工具鼠交配得直接全身表达Cas9蛋白的小鼠。 应用领域:基因敲除、基因修饰 *使用本品系发表的文献需注明: R26-CAG-Cas9 mice (Cat. NO. NM-KI-00120) were purchased from Shanghai Model Organisms Center, Inc.. ...
pCAG Cas9-2A-Citrine (Plasmid #92358) HH-CAS-160pU6-pegRNA-GG-acceptor(Plasmid #132777) HH-CAS-159pCMV-T7-ABEmax(7.10)-SpRY-P2A-EGFP (RTW5025)(Plasmid #140003) HH-CAS-157PB-TRE-dCas9-KRAB-MeCP2(Plasmid #122267) HH-CAS-158Lenti-eCas9(Plasmid #140237) HH-CAS-158 HH-CAS-...
R26-CAG-LNL-Cas9-IRES-Luc 品系全名 C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LNL-Cas9-IRES-Luciferase-pA) 目录号 NM-KI-18002 品系状态 活体 导出PDF 基因信息 基因名 Gt(ROSA)26Sor 基因曾用名 R26,ROSA26,AV258896,Gtrgeo26,Gtrosa26,Thumpd3as1 ...
为了筛选影响CAG重复扩增的遗传修饰因子,该团队构建了一个基于CRISPR-Cas9的体内基因编辑平台,利用腺相关病毒(AAV)递送sgRNA,在组成型表达Cas9的亨廷顿病小鼠模型中进行基因编辑,高效敲除目标基因并观察其对CAG重复扩增的影响。该团队首先针对...
Conclusions : The NOD.129(Cg)-Gt(ROSA)26Sortm1.1(CAG-cas9*,-EGFP)Fezh/J mouse would be a suitable model for optimising Cas9 knockdown in retinal ganglion cells or M眉ller cells, but may be a poor model for photoreceptor targets. The apparent lack of both Cas9 and EGFP in this model...
pCAG Cas9-2A-Citrine质粒 货号:#92358-20ul 货号产品名称规格库存价格数量购买 #92358-20ulpCAG Cas9-2A-Citrine质粒20ul 立即咨询 +- 产品介绍 相关产品 》产品信息 货号名称规格 #92358pCAG Cas9-2A-Citrine质粒 20ul 》产品描述 基因编辑 》产品简介 ...
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A single intracranial or intravenous injection of adeno-associated virus encoding for Cas9, a single-guide RNA targeting the HTT gene, and donor DNA containing the normal CAG repeat led to the depletion of mutant HTT in the animals and to substantial reductions in the dysregulated expression and ...
S0944-9 AAV2/9-CAG-spCas9/N-Intein(N-Npu DnaE)-WPRE-pA 价格: ￥500.00~6000.00 优惠: 200元优惠券,满1500可用 500元优惠券,满1500可用 评论:0条 收藏:0 腺相关病毒包装规格: 金标AAV 5ul ≥1E+13V.G./mL 金标AAV 20ul ≥1E+13V.G./mL 金标AAV 50ul ≥1E+13V.G./mL ...
(that is, relevance to in vivo instability in tissues) can be unclear. To bridge this gap, and with the goal of better understanding the factors and pathways that underlie somatic expansion, we have established an in vivo CRISPR–Cas9-based system for identifying somaticHTTCAG expansion-modifier...