3-Methylhistidine (3MH) has been proposed as a marker of muscle protein breakdown through the post-translational methylation of specific histidine residues in actin and myosin with clinical relevance as a predictor of myofibrillar proteolysis [54], while 3-MH-to-creatinine (3-...
Data on the skeletal muscle signaling pathways regulating protein synthesis and breakdown have been identified but not studied in cirrhosis [37]. Satellite cell biology has been extensively evaluated and its contributory role in sarcopenia of aging identified [88]. However, there are no studies that...
It is therefore possible, that atrogin-1 leads to muscle atrophy by selective breakdown of key regulators of protein synthesis [76]. We emphasise once more, that sepsis-mediated muscle wasting and ICU-acquired weakness should not be used synonymously, as ICUAW weakness represents its own entity,...
In animal studies, adipose tissue breakdown has been described as an essential component in the pathophysiology of cancer cachexia and that blocking lipolysis may be an important treatment strategy [67]. In humans, fat mass can also be accurately ascertained through cross-sectional imaging [68] and...
The Premier Departmental Research of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, Japan 3 Kano General Hospital, Osaka 531-0041, Japan * Author to whom correspondence should be addressed. Int. J. Mol. Sci.2021,22(16), 8491;https://doi.org/10.3390/ijms22168491 ...