or any other external radiotherapy lasting at least 5 days to sites other than bone within 4 weeks of receiving the first dose of study therapy; had clinically relevant ongoing major complications associated with prior radiotherapy; or if they ...
Withhold CABOMETYX for hypertension that is not adequately controlled with medical management; when controlled, resume CABOMETYX at a reduced dose [see DOSAGE AND ADMINISTRATION]. Permanently discontinue CABOMETYX for severe hypertension that cannot be controlled with anti-hypertensive therapy or for ...
Management of dose variability and side effects for individualized cancer pharmacotherapy with tyrosine kinase inhibitors Pharmacol Ther., 152 (2015), pp. 125-134 [11] H.J. Klumpen, C.F. Samer, R.H. Mathijssen, J.H. Schellens, H. Gurney ...
(16% Grade 3 and <1% Grade 4) of CABOMETYX patients. Do not initiate CABOMETYX in patients with uncontrolled hypertension. Monitor blood pressure regularly during CABOMETYX treatment. Withhold CABOMETYX for hypertension that is not adequately controlled with medical management; when controlled, resume ...
(16% Grade 3 and <1% Grade 4) of CABOMETYX patients. Do not initiate CABOMETYX in patients with uncontrolled hypertension. Monitor blood pressure regularly during CABOMETYX treatment. Withhold CABOMETYX for hypertension that is not adequately c...
(16% Grade 3 and <1% Grade 4) of CABOMETYX patients. Do not initiate CABOMETYX in patients with uncontrolled hypertension. Monitor blood pressure regularly during CABOMETYX treatment. Withhold CABOMETYX for hypertension that is not adequately controlled with medical management; when controlled, resume ...
We saw grade 3/4 adverse effects [AEs] in 55% of patients, but most of them were altered taste, fatigue, and diarrhea, which are hallmarks of TKI-related AEs. Grade 4 AEs only occurred in 4% of patients, so most of the AEs are manageable with dose reduction or symptom management. ...
(ACTH) level, and thyroid function at baseline and periodically during treatment with OPDIVO and before each dose of YERVOY. In cases of suspected immune-mediated adverse reactions, initiate appropriate workup to exclude alternative etiologies, including infection. Institute medical management pr...
Withhold CABOMETYX for hypertension that is not adequately controlled with medical management; when controlled, resume at a reduced dose. Permanently discontinue CABOMETYX for severe hypertension that cannot be controlled with anti-hypertensive therapy or for hypertensive crisis. Diarrhea: Diarrhea occurred...