1.TROPIC试验 TROPIC(Treatment of Refractory Prostate Cancer with Cabazitaxel and Prednisone International Clinical Trial)是一项多中心、随机、开放标签的III期临床试验,旨在评估卡巴他赛联合泼尼松与米托蒽醌联合泼尼松在治疗多西他赛失败后的转移性激素难治性前列腺癌患者中的疗效和安全性。 试验设计:该研究...
Clinical Trials as TopicProstate cancer is the second most frequently diagnosed cancer in men and the fifth most common cancer overall. Globally, more than 900,000 new cases of prostate cancer will be diagnosed in 2010 and more than 260,000 will, unfortunately, die from the disease. In the ...
Challapalli and colleagues (2021) stated that neoadjuvant cisplatin-based combination chemotherapy improves survival in muscle-invasive bladder cancer; however, response rates and survival remain suboptimal. In a single-arm, phase-II clinical trial, these researchers examined the safety, , safety, tolera...
Gastrointestinal (GI) Adverse Reactions:Nausea, vomiting, and severe diarrhea may occur. Death related to diarrhea and electrolyte imbalance occurred in the randomized clinical trials and mortality related to diarrhea has been reported. Intensive measures may be required for severe diarrhea and electrolyte...
This study is registered at ClinicalTrials.gov, NCT00417079 二:卡巴他赛增溶剂的选择,稳定溶液可用于体内实验 1 材料 卡巴他赛4g,HPCD(美仑货号MB1904)0.8克,冰醋酸适量,活性炭0.1克,无菌纯水100ml(美仑货号MA0028). 2工作液配置方法。取无菌纯水,降温至30-40℃,加入卡巴他赛搅拌使完全溶解,加入HPCD搅拌...
Clinical development of cabazitaxel for the treatment of castration-resistant prostate cancer[J]. Clin Med Insights Oncol. 2011, 5:163–9. Dieras V, Lortholary A, Laurence V, et al. Cabazitaxel in patients with advanced solid tumours: results of a phase I and pharmacokinetic study[J]. Eur...
Clinical trial identification EudraCT 2013-000286-36. Legal entity responsible for the study Institut Gustave Roussy. Funding Sanofi. Disclosure G. Baciarello: Financial Interests, Personal, Advisory Board: Janssen; Financial Interests, Personal, Invited Speaker: Roche; Financial Interests, Personal, Advis...
journal of clinical oncologyDe Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JH, Shen L, et al. Cabazitaxel or mitoxantrone with prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with docetaxel: final results of a ...
2020) or to the acute respiratory distress syndrome that was observed in patients treated with a polymeric nanoformulation of doxorubicin in a phase II clinical trial (Merle et al. 2017). No adverse long-term effects on the animals were observed in response to the additional sonopermeation ...
Real-life survival with cabazitaxel in FUJI was shorter than in TROPIC (pivotal trial, median OS 15.1 months) or PROSELICA (clinical trial 20 vs 25 mg/m2, median OS, respectively, 13.4 and 14.5 months). There was no effect of treatment-line on survival. No unexpected adverse concerns we...