Moreover, downstream of Wnt5a, we observed sharp downregulation of NFATc2 transcription factor expression, the major target of pesticide toxicity and its target molecule IFN-纬. Taken together, our result suggests that deregulation of Wnt5a-Ca2+-NFAT signaling axis in the hematopoietic stem/...
Please note, immortalized β-cell lines have abnormal rates of apoptosis and replication and likely have abnormal activation of Ca2+ signaling pathways; therefore, conclusions derived from cell lines should be verified in primary cells. Furthermore, inhibiting NFAT with the CaN inhibitor tacrolimus (...
钙库操纵性钙内流(SOCE) TCR信号通过PLC-γ介导细胞内Ca2+浓度升高,通过激活下游多种酶分子介导T细胞活化,其中最重要的靶分子就是NFAT。 IP3首先激活内质网(ER)释放Ca2+进入细胞质,ER膜上的STIM1感应到ER内Ca2+浓度下降后易位到细胞膜上,随后激活ORAI1引起Ca2+持续流入。 ORAI缺陷 ORAI负责调节内源储存介导的C...
(blue, 9 genes, FDR = 2.06E−02), “voltage-gated calcium channel activity” (green, 6 genes, FDR5.50E−04), calcium signaling pathway (pink, 8 genes, FDR = 4.89E−02), and “presynaptic depolarization and calcium channel opening” (light blue, 3 genes, FDR =...
Ca2+/nuclear factor of activated T-cells (Ca2+/NFAT) signaling pathway may play a crucial role in the pathogenesis of Kawasaki disease (KD). We investigated the poorly understood Ca2+/NFAT regulation of coronary artery endothelial cells and consequent dy
Since hypertonic stress occurs during hyperglycemic crisis in patients with diabetes, we sought to evaluate the effects of sustained (1–2 days) and elevated glucose (25–50 mM) on endogenous NFAT5 activity and Ca2+ signaling in skeletal muscle fibers in culture. Exposure to high glucose ...
However, the Ca2+-sensitive decoder coupling endothelial Ca2+ signaling to PI3K activations remains to be elucidated. 4.3. Calcineurin and NFAT VEGF-induced endothelial Ca2+ signaling may also recruit the Ca2+-sensitive transcription factor, NFAT (Figure 2), which regulates a transcription program ...
Braunewell, K.-H. The darker side of Ca2+signaling by neuronal Ca2+-sensor proteins: from Alzheimer's disease to cancer.Trends Pharmacol. Sci.26, 345–351 (2005). ArticleCASPubMedGoogle Scholar Kabbani, N., Negyessy, L., Lin, R., Goldman-Rakic, P. & Levenson, R. Interaction with...
We propose that calcineurin-AKAP79 scaffolding promotes NFAT signaling by balancing strong recruitment of calcineurin with its efficient release to communicate with NFAT. This is a preview of subscription content, log in via an institution to check access. Similar content being viewed by others ...
CaMKII is phosphorylated and activates the CREB/ATF and ERK signaling pathways, which induce changes in osteoblast functions7. Calcineurin (Cn) is another protein complex that responds to Ca2+signaling. Upon binding to Ca2+/CaM, Cn directly binds to and dephosphorylates the NFAT transcription factor...