进一步的研究发现,TMCO1基因敲除小鼠能够模拟痴呆-颅面胸畸形患者的主要病理特征,并证实了模型小鼠中细胞的钙稳态确实存在严重的失衡,推测内质网中钙浓度过高很可能是导致患者痴呆和颅面胸畸形的主要原因。 这些研究5月20日在线发表于Cell上...
以上结果表明受精卵中DNA甲基化的异常不足以造成着床前胚胎发育异常,这提示造成缺失母源NLRP14的胚胎2-cell阻滞的主要原因仍然不明。 为了找出Nlrp14mNull小鼠胚胎发育停滞的原因,研究团队进行卵母细胞纺锤体置换(spindle-transfer)实验,...
ASPET Pharmacological Reviews (2011).2. Berridge M.J., Lipp P., Bootman M.D. The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol. (2000).3. Iversen P. W., Eastwood B. J., Saittampalam G. S., Cox
他们从柑橘绿霉病菌(Pd)中鉴定出一种进化上保守的效应子 PdCDIE1(Penicillium digitatum Cell Death - Inducing Effector 1),并对其调节植物细胞死亡的具体机制进行了深入研究。该研究成果发表在《Nature Communications》上,为我们理解病原菌与水果的相互作用提供了全新的视角,对防治植物病害具有重要意义。 研究人员运用...
[1] Pollard, T. D. & Cooper, J. A. Actin, a central player in cell shape and movement. Science 326, 1208–1212 (2009). [2] Carlier, M. F. & Pantaloni, D. Direct evidence for ADP-P¡-F-actin as the major intermediate in ATP-actin polymerization. Rate of dissociation of P...
Cell—科学家实现皮层Ca2+信号和BOLD-fMRI信号的同步记录2020 11/12 神经科学临床和基础 个人 + 分享 神经科学临床和基础 A- A+ 科学研究相关。 本文由作者自行上传,并且作者对本文图文涉及知识产权负全部责任。如有侵权请及时联系(邮箱:guikequan@hmkx.cn) 关键词: 皮层信号科学 31人点赞 1人收藏 ...
它们保守的捕蝇草结构域(VFT)能结合L氨基酸或者其衍生物,从而使受体发生构象变化,形成紧密的二聚体激活态构象。随着冷冻电镜技术方法的飞速发展,C型GPCR的结构研究取得了重要进展,其中mGluR5 (Nature2019)和GABAB (Nature 2020, Cell Research 2020) 的全长结构最近相继得到解析。钙敏感受体CaSR作为C型GPCR的...
[7] Langton AK, Herrick SE, Headon DJ. An extended epidermal response heals cutaneous wounds in the absence of a hair follicle stem cell contribution. J Invest Dermatol. 2008;128(5):1311–1318. doi: 10.1038/sj.jid.5701178. [8] Cianferotti L, Cox M, Skorija K, Demay MB. Vitamin ...
[18] Ibrahim, Hazem Ahmed Hamed. "Pathogenesis of B-cell post-transplant lymphoproliferative disorders and HIV-associated B-cell lymphomas." (2010).[19] Palma, Giuseppe, et al. "Plasmacytoids dendritic cells are a therapeutic target in anticancer immunity." Biochimica et Biophysica Acta (BBA)-...
(IgE) and its meschanism was investigated through establishing the sensitized cell model in rat basophilic leukemia (RBL-2H3) cells using dinitrophenylated (DNP)-bovine serum albumin (BSA)-IgE. The results showed that cAMP interfered with sensitized cells, effectively inhibited the occurrence of ...