Interestingly, Drosophila CRELD1 mutants exhibited a strong PD-like locomotion deficit, mitochondrial hyperfusion, and complex I deficits with aberrant ROS signaling which possibly affected dopaminergic neurons activity [169]. 4.3. Alterations of lysosomes-mitochondria contacts in PD Lysosomes-mitochondria (...
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(blue, 9 genes, FDR = 2.06E−02), “voltage-gated calcium channel activity” (green, 6 genes, FDR5.50E−04), calcium signaling pathway (pink, 8 genes, FDR = 4.89E−02), and “presynaptic depolarization and calcium channel opening” (light blue, 3 genes, FDR =...
Therefore, it is highly possible that the V494I mutation might change the IP3 and/or IRBIT affinity to IP3R1, resulting in altered IP3R-triggered Ca2+ signaling. SCA29 is an autosomal dominant neural disorder, which is caused by mutations in the ITPR1 gene. However, clinical features of ...
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在此背景下,2023年06月15日四川大学华西医院麻醉科蒋若天课题组在Glia发表题为“Disrupting cortical astrocyteCa2+signaling in developingbrain induces social deficits and depressive-like behaviors”的论文揭示了在发育中的大脑中破坏皮质星形胶质细胞Ca2+信号会导致社交缺陷和抑郁样行为的机制。
英文名:Ruthenium red, Ca2+ signaling inhibitor;Ammoniated ruthenium oxychloride CAS号:11103-72-3 结构式:N.N.N.N.N.N.N.N.N.N.N.N.N.N.O([Ru+2])[Ru+2]O[Ru+2].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-] 分子式:H42Cl6N14O2Ru3 ...
Ruthenium red（钌红）基础信息 中文名：钌红;Ca2+信号抑制剂;钙离子信号抑制剂 英文名：Ruthenium red, Ca2+ signaling inhibitor;Ammoniated ruthenium oxychloride CAS号：11103-72-3 结构式：N.N.N.N.N.N.N.N.N.N.N.N.N.N.O([Ru+2])[Ru+2]O[Ru+2].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-]....
Intracellular Ca2+signaling is considered to be important for multiple astrocyte functions in neural circuits. However, mice devoid of inositol triphosphate type 2 receptors (IP3R2) reportedly lack all astrocyte Ca2+signaling, but display no neuronal or neurovascular deficits, implying that astrocyte Ca2...