Ionomycin (free acid), Ca2+ ionophore CAS号: 56092-81-0 MDL Number: MFCD06798385 MF(分子式): C41H72O9MW(分子量): 709.00 EINECS:Reaxys Number: Pubchem ID:Brand:BIOFOUNT Ionomycin (free acid) 是一种强效、高选择性的 Ca2+ 离子载体。 Ca2+ 的有效移动离子载体,对二价阳离子具有高度特异性(...
Focuses on the effects of calcium oxide ionophore ionomycin on insulin-stimulated and basal glucose transport in muscle. Muscle incubations; Inhibition of ionomycin of insulin-stimulated glucose; Measurement of glycogen phosphorylase activity; Influx of Ca2+ into the cytoplasm.Lee...
2d). Interestingly, the Ca2+ ionophore Ionomycin inhibited phagosome acidification. This suggests that a sustained, global influx of Ca2+ is detrimental to phagosome maturation; alternatively, Ionomycin may provide a conduit for phagosomal H+ efflux33 to inhibit maturation. In summary, the siRNA ...
Stimulation with the Ca2+ ionophore ionomycin and the sarco-/endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor thapsigargin in the presence of extracellular EGTA, a Ca2+-chelating agent, revealed dysregulated intracellular Ca2+ homeostasis in fibroblasts of P1 (Supplementary Fig. 5A, B). When ...
CsA dramatically reduced the staurosporine apoptotic effects on Ba/F3 cells, having no significant influence on ionomycin treatment. Thus, we can consider that the calcium ionophore ionomycin is not inducing MPTP opening and apoptosis of Ba/F3 cells, although is increasing [Ca2+]c and [Ca2+]mt....
In contrast, significant increases in mEPSC frequency were produced in BoNT-treated, but not TeNT-treated, cultures by application of the Ca2+ ionophore ionomycin in the presence of 10 mM [Ca2+]o. The frequency of sEPSCs was increased in BoNT-treated, but not TeNT-treated, cultures by ...
As expected, treatment with the C a2+ ionophore ionomycin (1 μM) boosted Jacob's intensity within the nuclear matrix and, concomitantly, reduced its intensity at the nuclear periphery (Fig. 2k–l). Dissociation of Jacob from LaminB1 and binding to CREB is regulated by...
Ca 2+ ionophores and the activation of human-blood platelets-the effects of ionomycin, beauvericin, lysocellin, virginiamycin-s, lasalocid-derivatives and MCN-4308 . Biochimica et Biophysica Acta , 598 , 575 – 587 .Massini P, Naf U. Ca2+ ionophores and the activation of human blood ...
To this end, cells were incubated for 1.5 h at 4 °C in Krebs Ringer modified buffer (KRB, 125 mM NaCl, 5 mM KCl, 1 mM Na3PO4, 1 mM MgSO4, 5.5 mM glucose, 20 mM HEPES, pH 7.4, 37 °C), supplemented with the Ca2 + ionophore ionomycin (5 μM), 600 μM EGTA and 5 μ...
(Fig.2a, band Supplementary Fig.4c). Moreover, treatment of cells with the calcium ionophore ionomycin triggered an accumulation of EqtSM in numerous puncta, but only when calcium was present in the medium (Fig.2c, dand Supplementary Fig.1a). The plasma membrane of mammalian cells harbors ...