CA19-9在临床上主要用于胰腺癌的诊断,但在一些良性疾病中也会升高,如胰腺炎、肝炎、胆道炎症及梗阻性疾病等。在其它恶性肿瘤中也会升高,如子宫内膜癌、卵巢癌等生殖系统肿瘤,肝癌、胆管癌、结直肠癌等消化系统癌肿瘤[7]。虽然CEA不是一种特异性的肿瘤标志物,但CEA...
说明97.8% 的CA19-9升高是非肿瘤原因,约40%的无明显原因,超过50%的原因可以解释为胃肠 、肝胆 、生殖和内分泌系统的良性疾病,其中以甲状腺结节为主的甲状腺疾病占9.6%(53/548),子宫肌瘤和卵巢囊肿为主的女性生殖系统疾病占11.9%。良性胃肠、肝胆疾病和糖尿病患者CA19-9升高报道也较多。 有报道在261例CA19-9升...
CA19-9Pancreatic cancerResectabilitySensitivitySpecificityCA19-9 serum has been suggested as a marker of unresectability but different cut-off levels have been published. A cut-off of 500 U/ml is currently considered in an international consensus as biological criteria of borderline resectable ...
negative pancreatic cancer: An aggressive subgroup. Chen Liu, Shengming Deng, Kaizhou Jin,et al.Int J Oncol. 2020 Apr;56(4):900-908. doi: 10.3892/ijo.2020.4989. 2. Potential Biomarkers in Lewis Negative Patients With Pancreatic Cancer. Guopei Luo, Chen Liu, Meng Guo,et al. Ann Surg. ...
Comparative study of CA242 and CA19-9 for the diagnosis of pancreatic cancer.[J]. British Journal of Cancer, 1994, 70(3):481-486。 刘立民, 张宗明, 刘卓,等. 血清CA19-9异常增高的胆总管结石7例诊治体会[J]. 外科(汉斯), 2017, 006(001):P.8-12. Ji-Cong, Gui, Wei-Li,等. CA19-9...
3. Luo G, Jin K, Deng S, Cheng H, Fan Z, Gong Y, Qian Y, Huang Q, Ni Q, Liu C, Yu X. Roles of CA19-9 in pancreatic cancer: Biomarker, predictor and promoter. Biochim Biophys Acta Rev Cancer. 2020 Aug 19:188409. doi: 10.1016/j.bb...
BioNTech今年5月收购了MabVax Therapeutics的I期候选药物MVT-5873,这是一种针对CA19-9的抗体。2018年2月公布了35名患者的中期阳性数据。据报道,MabVax还在开发一种针对CA19.9的CAR-T免疫肿瘤疗法。 相信,不远的未来,这些疾病都将攻克! 参考资料: [1] In Pancreatitis and Pancreatic Cancer, a Supposed Bystander ...
相关研究结果发表2019年6月21日的Science期刊上,论文标题为“The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice”。论文通讯作者为冷泉港实验室癌症中心主任David Tuveson。 对R;F CA19-9小鼠模型进行胰腺谱系免疫荧光分析,图片来自Tuveson lab/CSHL 2019。
CA 19-9: Biochemical and Clinical Aspects. PMID: 26530370 Comparing the diagnostic accuracy of five common tumour biomarkers and CA19-9 for pancreatic cancer: a protocol for a network meta-analysis of diagnostic test accuracy. PMID: 29282264 ...
2019年6月21日,美国冷泉港实验室David A. Tuveson团队在Science 在线发表题为“The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice”的研究论文,该研究使用基因工程,该创建了一个小鼠模型,表达FUT3和半乳糖基转移酶β3GALT5,允许产生CA19-9。值得注意的是,CA19-9在小鼠中的表达导致快速和...