Ca Channel Blockersdoi:10.1007/978-3-030-57401-7_34Striessnig, JrgLeopold-Franzens-Universität InnsbruckOrtner, Nadine J.Leopold-Franzens-Universität Innsbruck
钠通道钠通道 维持细胞膜兴奋性及传导维持细胞膜兴奋性及传导2.2.钙通道钙通道 外钙内流外钙内流3.3.钾通道钾通道 电压依赖性钾通道电压依赖性钾通道4.4.氯通道氯通道 钙通道阻滞药钙通道阻滞药Calcium Channel Blockers 目目 的的 要要 求求 钙通道阻滞药作用方式及分类,钙通道阻滞药作用方式及分类,每类代表...
目前治疗PAH的药物包括钙离子通道拮抗剂(calcium channel blockers,CCBs)、内皮素受体拮抗剂(endothelin receptor antagonists,ERAs)、磷酸二酯酶-5抑制剂(phosphodiesterase type 5 inhibitors,PDE-5)、前列环素类似物和前列环素受体激动剂以及可溶性鸟苷酸...
Calcium channel antagonists delay regression of androgen-dependent tissues and suppress gene activity associated with cell death. Prostate 1988; 13: 119-30. Olsen JH, Sorensen HT, Friis S et al. Cancer risk in users of calcium channel blockers. Hypertension 1997; 29: 1091-4. Hole DJ, Gillis...
CalciumChannelBlockers 掌握 钙通道阻滞药药理作用、临床应用、不良反应。了解 钙通道阻滞药作用方式及分类,每类代表药物及体内过程等。Ca2+生理意义 血液凝固心脏搏动NC兴奋性N递质释放肌肉收缩腺体分泌C运动磷脂酶激活基因表达 Ca2+通道的类型 受体调控性钙通道(ROC)电压依赖性钙通道(VDC)L型、T型、N型、P型...
7.03 – Progress in the Discovery of Ca Channel Blockers for the Treatment of PainThere has been considerable progress in the medicinal chemistry of voltage-gated ion channels in the last decade. A number of targets within the family have the highest level of validation, namely, clinical...
3) L-type Ca channel blocker 钙离子通道阻断剂 例句>> 4) L-type calcium channel blockers L-型钙通道阻断剂 1. Effects ofL-type calcium channel blockerson tramadol-induced analgesia in mice; L-型钙通道阻断剂对曲马多镇痛作用的影响 5) calcitonin gene-related peptide receptor antagonist (CGRP8-...
calcium channel blockers 又称“钙拮抗剂”、“慢通道阻滞剂”。指能选择性的阻滞细胞膜上的钙通道,减少Ca2+经钙通道内流的一类药物。主要有二氢吡啶类(如硝苯吡啶、尼莫地平)苯烷胺类(如维拉帕米)和硫氮■类(如硫氮■酮)等。在钙通道蛋白上有此三类药物的高亲和力结合位点。具有扩张血管、降低血压、减弱心...
K-Ca channel blockers reveal hyperpolarization and relaxation to K+ in rat isolated mesenteric artery Dora, KA, Ings, NT, Garland, CJ (2002) K(Ca) channel blockers reveal hyperpolarization and relaxation to K+ in rat isolated mesenteric artery. American Journal of Physiology Heart and Circulator...
The effects of Ro 40-5967, a nondihydropyridine Ca++ channel blocker, on low-voltage activated (T-type) and high-voltage activated (L-type) Ca++ channels were compared. L-type barium currents were measured in Chinese hamster ovary cells stably transfected with the alpha 1 subunit of the cla...