CA125 was evaluated as a covariate but not found to be significantly associated with chemotherapy toxicity and not included in the multivariate analysis. The disparate results in CA125 level association with toxicity may be explained by the differences in their patient population. The GINECO study ...
Conclusions: The linear prediction model explained a small portion of the total variability of CA125, suggesting the need to identify novel predictors of CA125. The dichotomous prediction model showed moderate discriminatory performance which validated well in independent dataset. Our dichotomous model ...
"The hypothesis is that CA-125 directly binds to farletuzumab, thereby interfering with its complement- and antibody-mediated tumor cellular cytotoxicity,” Herzog explained. The primary objective of the phase 2 study was to determine whether farletuzumab in addition to carboplatin...
By comparing the clinical data of OM and NOM patients, we found that CA-125 was significantly elevated and Hb concentration was decreased in the OM patients compared with that in the NOM group (P < 0.05). There were no significant differences in serum levels of CEA, CA-724, CA-199, CA...
), Ferraro et al. [25] did not report significant different levels of HE4 in 103 patients according to BMI, probably explained by inclusion of men and women in this study which should constitute a bias. In conclusion, serum HE4 levels appeared to not be modified by the BMI, as CA125....
In fact, the mechanism of regulation of MUC16 expression has not yet been explained. Recently, Azad et al. [26] reported the results of a trial with sorafenib and bevacizumab in 42 patients with EOC evaluated both by RECIST and CA125 response criteria. Although the number of patients in ...
However, the diagnosis should be entertained in the presence of abnormal vaginal bleeding not explained by gynaecological examination and biopsy of the cervix and endometrium. The possibility of tubal carcinoma should be considered in patients with persistent vaginal discharge and lower abdominal pain ...
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Such techniques are explained fully in the literature (see, e.g., Maniatis, Fritsch & Sambrook, “Molecular Cloning: A Laboratory Manual (1982); “DNA Cloning: A Practical Approach,” Volumes I and II (D. N. Glover ed. 1985); “Oligonucleotide Synthesis” (M. J. Gait ed. 1984); “...