The present invention relates to the treatment and prevention of diseases complement to use such antibodies as well as antibodies to C3b is involved. In one embodiment, the present invention, or prevention of disorders comprising administering to a subject in need an effective amount of a C3b ...
nucleotide bindingmagnesium ion bindingprotein binding5'-nucleotidase activityesterasehydrolasemetabolite interconversion enzyme 参与通路 nucleotide metabolic processdephosphorylationexonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2Answer...
In the immune system, CD72 serves as a low-affinity receptor for Sema4D (7) and research studies have shown that Sema4D not only regulates T-cell activation (8,9) but is also involved in the regulation of B-cell survival and differentiation (5). Many of the physiologic effects of Sema...
Typical example trajectories of C3b-beads during phagocytosis are shown in Fig.3D,E (blue curves), depicting the recorded bead positions as a function of time. The resulting bead traces allow us to quantify the amount of initial target push-out and the speed at which each particle is pulled...
Neither of the mutations caused any overall structural changes in FH19–20. It is thus evident that Q1139 in domain 19 and R1203 in domain 20 are directly involved in binding to the C3d part of C3b and therefore both the domains are involved in the interaction with C3d and C3b. This...
CR1 and CR2, which are expressed by cells involved in the immune response, are likely to have important roles in clearance, processing and presesntation of antigen, and in modulating the proliferation and differention of B cells. The complete primary structure of both receptors is now known. ...
Red boxes indicate loss-of-function variations and the cyan box indicates a gain-of-function, suggesting that it is perhaps not involved in aHUS (Nilsson, S. C. et al. Eur. J. Immunol. 39, 310–323, 2009). (c) Disease-related mutations on FH at the FH-FI interface. Residues on ...
We found that C4BP requires all four N-terminal CCPs of the α-chain, with CCP2 and 3 being the most important, to act as a cofactor in the cleavage of C3b. Also, a cluster of positively charged amino acids on the interface between CCP1 and 2 is involved in the binding. Compared ...
These results provide further evidence that a primary mechanism involved in the observations outlined here is the ability of C3b to block interaction between CD16 and the Fc portion of human IgG1. The ability to induce complement fixation varies depending on the mAb. Different anti-CD20 mAbs ...
It has neurotrophic/neuroprotective effects by mediating the actions of neurotrophic molecules in the brain, thus providing neuroprotection through modulation of energy metabolism. Notably, it has been demonstrated that GSK3β is involved in Wnt-beta-catenin signaling, which contributes to the inhibition...