方法:(1)基于人体肿瘤基因组图谱(The cancer genome atlas,TCGA)数据库使用R软件(版本3.6.3)进行在泛癌以及口腔鳞状细胞癌中C1QTNF6的分析和可视化,并且制作C1QTNF6诊断依赖性受试者工作特性曲线(receiver operating characteristic curve,ROC),评估该因子对于口腔鳞状细胞癌的诊断效能.使用R软件筛选在口腔鳞状细胞癌...
Conclusions These results suggested that C1QTNF6 play a promoting role in OSCC tumorigenesis, which may be a promising therapeutic target for OSCC treatment.doi:10.21203/rs.3.rs-245470/v1Xiaobin SongLongjie LiLiang ShiXinyu LiuKetao WangBioMed CentralCancer Cell International...
C1QTNF6lung adenocarcinomamiR-29a-3pcytokine-cytokine receptor interaction pathwayObjective: Non-small cell lung cancer(NSCLC) is a major type of lung cancer with high morbidity and high mortality. Currently, there is a lack of valuable predictors for the recurrence and progression of early-stage ...
Results C1QTNF6 was upregulated in stage I LUAD tissues compared with adjacent non-cancerous tissues. Concurrently, C1QTNF6 knockdown could remarkably inhibit cell proliferation, migratory and invasive abilities, while overexpression of C1QTNF6 presented opposite results. Additionally, miR-29a-3p may ...
In addition, we performed experiments to investigate the biological function of C1QTNF6 on cancer cells in vitro. The siRNA strategy was conducted to decrease the C1QTNF6 expression and then Cell Counting Kit-8 (CCK8) assay and wound-healing and transwell assays were to determine the ...