A close association between obesity, diabetes, and insulin resistance has been identified, and many studies have pinpointed obesity as a causal risk factor for insulin resistance. However, the mechanism underlying this association is not entirely understood. In the past decade, ceramides have gained...
Ceramides are an integral part of cell membranes associated with macrodomains regulating surface receptors and signaling pathways [18,19,20,21,22,23]. Previous studies addressing the role of ceramide in diabetes focused on insulin resistance [12,13,24,25] and did not address diabetic complications...
inflammatory responses in humansMediators Inflamm.2015120748(2015) 2.Rico, J.E., Bandaru, V.V., Dorskind, J.M., et al.Plasma ceramides are elevated in overweight Holstein dairy cows experiencing greater lipolysis and insulin resistance during the transition from late pregnancy to early lactation...
Homeostatic Model Assessment for Insulin Resistance; IR: insulin resistance; LDH: lactate dehydrogenase; MRM: multiple reaction monitoring; mRNA: messenger RNA; obese-DM: obese-diabetic; obese- NDM: obese non-diabetic; PCR: polymerase chain reaction; PKB: protein kinase B; PT: prothrombin time; ...