Expression of C1 esterase inhibitor by the baculovirus expression vector system: preparation, purification, and characterization. Protein Expr. Purif. 22: 414-421.Wolff MW, Zhang F, Roberg JJ, et al. Expression of C1 esterase inhibitor by the baculovirus expression vector system: preparation,...
C1 inhibitor/C1-INH 蛋白名称 推荐名 Plasma protease C1 inhibitor 简称 C1 Inh||C1Inh 别名 angioedema, hereditary, C1IN, C1-INH, HAE1, HAE2, plasma protease C1 inhibitor 其他名 C1 esterase inhibitorC1-inhibiting factorSerpin G1 From Uniport ...
Hereditary angioedema (HAE) is a rare autosomal dominant disease due to C1 esterase inhibitor deficiency (C1-INH). The disease is characterized by subcutaneous and submucosal edema in the absence of urticaria due to the accumulation of bradykinin. This descriptive study aimed to evaluate the clinical...
The syndrome of acquired angioedema and C1-inhibitor deficiency is associated with B-cell lymphoproliferative disease. It is characterized by accelerated consumption of C1q and C1 inhibitor in vivo and by low levels of serum C2 and C4. Four patients with B-cell malignant diseases (IgA myeloma, ma...
(Fig. 19-2). The C1q protein binds to theFc region of Igs, while the cleavage activity of C1 as a whole rests in theserineesterase activities of the C1r and C1s components. The C1r and C1s proteins are both single-chain polypeptides of about 85 kDa. Each contains two domains, one ...
For high fat diet (HFD) feeding, 8 weeks old mice were fed the original HFD formula (60 kcal% fat, D12492; Research Diets) for the indicated period of time. Phospho-diesterase 4 (PDE4) inhibitor, rolipram (5 mg/ kg), was given intraperitoneally (IP) either acutely for 12 ...
biomolecules Article A Novel C1-Esterase Inhibitor Oxygenator Coating Prevents FXII Activation in Human Blood Katharina Gerling 1, Sabrina Ölschläger 1, Meltem Avci-Adali 1, Bernd Neumann 1, Ernst Schweizer 2, Christian Schlensak 1, Hans-Peter Wendel 1 and Sandra Stoppelkamp 1,* 1 ...
a research grant from the Department of Research of the University of Basel (Basel, Switzerland), and a research grant from the Fondation Machaon, Switzerland (a not-for-profit private foundation, Geneva, Switzerland; to Dr. Osthoff). A recombinant C1 esterase inhibitor was provided by Pharming...
To elucidate the details of the esterase activity of human serum albumin, the reaction of N-trans -cinnamoylimidazoles with albumin was investigated kinetically at various pHs at 25°. The reaction consisted of the acylation of albumin (probably the tyrosine-411 residue) by the substrate and the...
This study further shows that modification results in significant loss of the esterase like activity of albumin. Since albumin plays a crucial role in the antioxidant defence due to its abundance (0.6mM) in serum, these findings have implications in disease states where increased levels of MDA ...