Only some domains in this family bind Ca2+ or sugars. A comparison of recent structures of C-type lectin-like domains reveals diversity in the modular fold, particularly in the region associated with Ca2+ and sugar binding. Some of this diversity reflects the changes that occur during normal ...
The superfamily of proteins containing the C-type (Ca-dependent) lectin-like domain (CTLD) is a large group of extracellular proteins characterized by evolutionary flexibility and functional versatility [1,2]. Its members have been extensively studied because of their involvement in diverse physiologic...
These lectins contain one or more C-type lectin-like domains (CTLD) and often bind to carbohydrates in a Ca2+-dependent manner (Drickamer, 1999, Takeuchi et al., 2008). CTLD-containing proteins are present in all metazoans and numerous non-metazoans (Cummings and McEver, 2009, Drickamer...
The C-type lectins are a superfamily of more than 1,000 proteins that are defined by having one or more characteristic C-type lectin-like domains (CTLDs). They have been subdivided... 查看全部>> LM Graham,GD Brown - 《Cytokine》 被引量: 0发表: 2009年 Myeloid C-type lectins in innate...
Clec14a is a type I transmembrane protein whose extracellular domain consists of a C-type lectin-like domain (CTLD), a series of epidermal growth factor-like domains, and a sushi-like domain. Rho et al.13 reported that clec14a is endothelial cell-specific and may have a key role in ...
C-type lectin-like domains in Caenorhabditis elegans: predictions from the complete genome sequence. Glycobiol 1999;9:1357-69 Drickamer K, Fadden AJ. Genomic analysis of C-type lectins. Biochem Soc Symp 2002;69:59-72 Duret L. Evolution of synonymous codon usage in metazoans. Curr Opin Gene...
C-type lectins belong to a superfamily of receptors that share structural homology in their carbohydrate recognition domains and often bind to carbohydrates in a Ca2+-dependent fashion. Whereas endocytic C-type lectin receptors (CLRs) trigger the receptor-mediated endocytosis of soluble ligands, ...
Abbreviations CDS: Coding sequence; cEGF: Complement C1r-like EGF domain; cbEGF: Calcium-binding EGF; CTLDcp: C-type lectin domain-containing protein; EC: Endothelial cells; ECD: Extracellular domain; EGF: Epidermal growth factor; FGFR1: Fibroblast growth factor receptor 1; MMRN2: Multimerin-...
•A novel protocol to produce and purify CD93 C-type lectin-like domain (CTLD) inEscherichia coli.•The CD93-CTLD contains disulfide bridges and does not bind to Ca2+.•The CD93-CTLD neutralizes lipopolysaccharide-induced inflammatory response of THP1 monocytes and cultured leukocytes.关键...
The extracellular portion of these receptors represent a subfamily of C-type lectin-like domains (CTLDs), which are divergent from true C-type lectins and are referred to as NK-cell domains (NKDs). We have determined the three-dimensional structure of human CD69 NKD in two different crystal...