Abnormally low amounts of C-peptide in the blood suggest that insulin production is too low or absent because of type I diabetes, also known as juvenile or insulin-dependent diabetes. Abnormally high amounts of C-peptide warn of the possible presence of insulinoma tumors, which secrete insulin...
You have low blood sugar,so your pancreas stops releasing insulin, or you're taking insulin so your pancreas isn't releasing any. Treatment has shrunk your insulinoma. Ask your doctor for more details about what your test results mean. Then, find out what treatment steps you'll need to tak...
C-peptide measurements are useful in insulinoma diagnosis, especially in patients treated with insulin. Elevated C-peptide levels are indicative of insulinoma. C-peptide measurements are useful in the need for progression to insulin therapy in non-insulin dependent diabetics (NIDDM). C-peptide ...
endogenously in the pancreas and stored in secretory granules in a 1:1 ratio with insulin; unlike factitious hypoglycemia, which is induced by insulin of exogenous origin, an increased C-peptide (= 0.2 nmol/L) as well as increased insulin (= 42 pmol/L) is characteristic of insulinoma. C...
In fact, measurement of C-peptide is used for diagnosis and therapy of diabetes, and is useful for diagnosis of insulinoma and insulin autoimmune syndrome. Usually, the ratio of C-peptide to proinsulin is about 1:0.6-1.3 in healthy individuals, about 1:0.3-0.5 in pyknic type individuals, ...
Measurement of plasma insulin aims to assess insulin production by the beta cells in diagnosis of insulin producing tumours (insulinoma) or other causes of low blood glucose. In addition, insulin analysis is used to characterize insulin resistance or to judge when type 2 diabetics need insulin as...
1.Introduction Insulin is self-administered by patients,usually by subcutaneous injection.It has been reported that insulin is sometimes used for suicide [1±4],but sel-dom for murder [5].The diagnosis of insulin toxicosis is dif®cult because insulin is present in normal human serum and ...
The absence of hypoglycemia <2.5 mmol/L during the fasting test and the absence of pancreatic lesions on the three abdominal CT scans performed prior to her hospitalization were not in favor of an insulinoma. Furthermore, the intake of insulin secretagogues (repaglinide and sulphonylurea [...
The ability of anle145c to protect living cells from hIAPP-induced cytotoxicity was tested using insulinoma (INS-1E) cells from a rat pancreatic beta cell line. These cells closely resemble the insulin-producing beta-cells in the pancreas that are known to become damaged under conditions of ...
Insulinomamalignant insulinomaproinsulinC-peptideinsulinThe value of plasma insulin, human C-peptide and proinsulin estimation in the diagnosis of 15 insulinomas has been investigated. Measurement of plasma proinsulin in an overnight fasting sample diagnosed all the insulinomas studied, irrespective of the ...