Jiang MR, Li YC, Yang Y and Wu JR: c-Myc degradation induced by DNA damage results in apoptosis of CHO cells. Oncogene 22: 3252-3259, 2003.Jiang MR, Li YC, Yang Y, Wu JR. 2003. c-Myc degradation induced by DNA damage results in apoptosis of CHO cells. Oncogene 22:3252-3259....
生物谷报道:c-Myc最初是作为1个原致癌基因发现的,活跃于很多人类肿瘤中,但它也是1种转录因子,是正常细胞生长和增殖所必需的。它影响基因表达的能力过去曾被认为是其促进肿瘤发育的手段,但关于c-Myc也影响DNA复制的发现直接表明,对于它的某些作用应有另1种解释。通过定位DNA合成点及与复制前复合体相结合,c-Myc能够...
c-Myc degradation induced by DNA damage results in apoptosis of CHO cells.Although tripchlorolide (TC), a compound purified from a Chinese herb Tripterygium Wilfordii Hook, has been demonstrated to be a potent antitumor agent, its mechanisms of action are unknown. The present study shows that ...
Keywords: MYC; DNA damage; apoptosis; P53; MDM2; in vivo Abbreviations: NMNU, N-methyl-N-nitrosourea; BET, bromodomain and extra-terminal; IHC, immunohistochemistry; Gy, gray Received 16.7.13; revised 13.12.13; accepted 08.1.14; Edited by G Melino; published online 28.2.14 an urgent ...
ｃ⁃Ｍｙｃ与肿瘤放射敏感性关系的研究进展 林兴华，秦性璋综述，赵玉婉，柳建军审校 ㊀㊀［摘要］㊀ｃ⁃Ｍｙｃ是一种致癌转录因子，其在肿瘤细胞的生长㊁细胞周期分布㊁ＤＮＡ损伤修复㊁上皮间质转化㊁自噬㊁肿瘤干细胞的形成以及基因组的维持中起重要作用㊂近年来对于ｃ⁃Ｍｙｃ基因的研究发现，...
Targeting DNA damage response promotes antitumor immunity through STING-mediated T-cell activation in small cell lung cancer[J]. Cancer Discov, 2019,9(5):646-661. DOI: 10.1158/2159-8290.CD-18-1020 . 返回引文位置Google Scholar 百度学术 万方数据 [23] Sen T , Della Corte CM , Milutinovi...
Here, we show that mice with severe isolated respiratory complex III (CIII) deficiency display nuclear DNA damage, cell cycle arrest, aberrant mitoses, and cellular senescence in the affected organs such as liver and kidney, and a systemic phenotype resembling juvenile-onset progeroid syndromes. ...
中部为酸性区(acidic region)、非特异性DNA结合(nonspe2 cial DNA binding,NDB)区及核定位信号(nuclear lo2 calization signal,NL S)区。C末端的85个氨基酸残基构成了b HL HZip,包括3个结构元件,它们分别被命名为碱性区(basic region,b),螺旋2环2螺旋(helix loop helix,HL H)区和亮氨酸拉链(leucine zipper...
Induction of bulk and c-mycP2 promoter-specific DNA damage by an anti-topoisomerase II agent salvicine is an early event leading to apoptosis in HL-60 cells Federation of European Biochermical Societies Letter 501: 59-64.Meng LH,Ding J.Induction of bulk and c-myc P2promoter-specificDNA ...
Objective:To evaluate effect of adipose-derived stem cells(ADSCs)on function of DNA damage repair in C57 mice with thymomas induced by irradiation.Methods:A total of 32 cleaning degree C57BL/6mice were d...