例如,TRIM21通过阻止突变型p53的积累来抑制癌症进展。此外,TRIM21通过降解电压依赖性阴离子通道蛋白2和CD47来调控肿瘤免疫。最近的研究(包括作者自己的研究)揭示了TRIM21在CRC肿瘤发生和进展中的重要作用。然而,TRIM21是否在KRAS突变型CRC...
c-Myc是一种广泛应用于分子生物学研究的蛋白质标签,主要用于目标蛋白的检测和纯化。其核心功能依赖于特定的氨基酸序列及灵活的应用场景,以下从序列结构、应用领域、纯化方法、位置选择及特性等方面展开说明。 1. 序列结构与功能 c-Myc标签的氨基酸序列为EQKLISEEDL,这一短肽序列具有高特异性,可被...
抑制C-Myc基因与肿瘤免疫微环境的相互作用 C-Myc基因可直接结合CD47和PD-L1基因启动子调节细胞表面CD47和PD-L1的表达,从而利于肿瘤生长。免疫检查点抑制剂可能成为治疗MM的新靶点。NCT02678338、NCT02953782、NCT02216409和NCT02953509等临床试验正在评估抗PD-L1的...
Hypoxic CD47 null mice demonstrated increased stroke volume and cardiac output compared to a significant deterioration of these functional parameters in wild type controls. Hypoxic wild type animals also displayed concurrent loss of cMyc and upregulation of endothelin-1. In contrast, hypoxic CD47 null...
(NK)细胞功能的影响,Western blot和免疫共沉淀实验检测c-Myc对Ⅰ类HDAC的作用,流式细胞术检测c-Myc对低表达的免疫激活性配体主要组织相容性复合体Ⅰ类链相关蛋白A和B(MICA/B)和Y亚型中高表达的免疫检查点分子CD47、细胞程序性死亡配体1(PD-L1)、CD155的调控作用及HDAC在其中的作用,染色质免疫沉淀检测和实时...
CD47 regulates renal tubular epithelial cell self-renewal and proliferation following renal ischemia reperfusion. Kidney Int. 2016;90:334–47. Article CAS Google Scholar Yilmaz S, Paavonen T, Hayry P. Chronic rejection of rat renal allografts. II. The impact of prolonged ischemia time on ...
et al. MYC regulates the antitumor immune response through CD47 and PD-L1. Science 352, 227–231 (2016). Article CAS PubMed PubMed Central Google Scholar Kress, T. R., Sabo, A. & Amati, B. MYC: connecting selective transcriptional control to global RNA production. Nat. Rev. Cancer ...
染色质免疫沉淀测序分析证实MYC通过与CD47及PD-L1的启动子结合,在转录水平直接调节二者的表达,从而抑制先天性和适应性抗肿瘤反应,有助于肿瘤的生长和维持[14]。WHO(2017)血液系统肿瘤分类中将伴有双打击/三打击的弥漫性大B细胞性淋巴瘤归类为高级别B细胞淋巴瘤(HGBL),以提示疾病的高侵袭性及高进展性,并指出DLBCL...
Casey SC et al (2016) MYC regulates the antitumor immune response through CD47 and PD-L1. Science 352(6282):227–231 CAS PubMed PubMed Central Google Scholar Cenci T et al (2012) Prognostic relevance of c-Myc and BMI1 expression in patients with glioblastoma. Am J Clin Pathol 138(3)...
Casey SC et al (2016) MYC regulates the antitumor immune response through CD47 and PD-L1. Science 352(6282):227–231 4. Cenci T et al (2012) Prognostic relevance of c-Myc and BMI1 expression in patients with glioblastoma. Am J Clin Pathol 138(3):390–396 5. Dang CV (2012) MYC ...