To disrupt c-myb gene expression, we have developed an approach that utilises reverse complementary, or 'antisense' oligodeoxynucleotides (ODN). Using this therapeutic strategy, we conducted clinical trials to evaluate the effectiveness of c-myb targetted ODNs as marrow purging agents. We have ...
药物名称:脱氧核糖核苷酸钠英文名:别名: DNA单核苷酸钠;脱氧核苷酸钠 ,脱氧核糖核苷酸钠适应症: 主要用于治疗急性白细胞减少症,对慢性白细胞减少症、再生障碍性贫血等也有一定疗效。 用量用法: 肌注:0.05g/次,1次/日,疗程不宜超过2～3周。冻干针剂临用前用等渗盐水或注射用水溶解。 规格: 针剂:0.05g/2ml;冻干...
MYB (MYB proto-oncogene, transcription factor) 该基因编码一种具有三个HTH-DNA结合域的蛋白质,作为转录调节器。这种蛋白在造血调节中起着重要作用。该基因可能在白血病和淋巴瘤中异常表达、重排或易位,被认为是癌基因。选择性剪接导致多个转录变体。 This gene encodes a protein with three HTH DNA-binding domain...
In addition, the carboxyl terminal region of human c-myb was placed in an expression vector to obtain protein for the generation of antiserum, which was used to identify the human c-myb gene product. Like v-myb, this protein was found within the nucleus of leukemic cells where it was ...
The c-myb gene is a nuclear DNA binding protein that has been implicated in myeloid transformation in a number of systems. The Evi-1 gene is a ... JN Ihle,M Kazuhiro,B Christopher,... - 《Stem Cells》 被引量: 0发表: 1996年 加载更多来源...
(4.9%)diedfromcardiovasculardiseaseoraccidentandothercauses.3 山东大学硕士学位论文Another32patients印a商∞∞sofbenignbreastm硼;s鹤we帕randomlyselectedtodoasoontrolofc-mybgeneexpression.Results:1.Theexpressionofc-mybgeneinbreastcancerandbenignbreasttissues(Immunohistochemistry).c-mybishighlyexpressedinbreastcance...
Two cDNA clones of the human c-myb gene have been isolated from a CCRF-CEM leukemia cell cDNA library and sequenced in their entirety. These sequences, when compared with those previously reported for the human c-myb gene, reveal an alternative splicing process that generates at least four fo...
关键词c-myc；c-myb；白血病；骨髓基质细胞 中图分类号R733．7文献标识码A Expression of c-myc and c-myb Gene in Leukemic Bone Marrow Stromal Cells and Their Correlation ZHANG Ying，CHEN Rui，ZHANG Wei，LI Juan，CHEN Xuan，ZHAO Li* Central Laboratory，The First Hospital of Lanzhou University，...
Phenomenon explanation:The possible reasons that the actual band size differs from the predicted are as follows:1.Splice variants: Alternative splicing may create different sized proteins from the same gene.2. Relative charge: The composition of amino acids may affects the charge of the protein.3....
3) gene [英][dʒi:n] [美][dʒin] 基因 1. Study of the Preparation and the Characteristics of pRc/CMV-BChE Gene-chitosan nanoparticles ①; 丁酰胆碱酯酶基因-壳聚糖纳米粒初步研究 2. Correlation between traditional Chinese medicine syndromes in primary immunoglobulin A nephropathy and A267...