MYB (MYB proto-oncogene, transcription factor) 该基因编码一种具有三个HTH-DNA结合域的蛋白质,作为转录调节器。这种蛋白在造血调节中起着重要作用。该基因可能在白血病和淋巴瘤中异常表达、重排或易位,被认为是癌基因。选择性剪接导致多个转录变体。 This gene encodes a protein with three HTH DNA-binding domain...
To disrupt c-myb gene expression, we have developed an approach that utilises reverse complementary, or 'antisense' oligodeoxynucleotides (ODN). Using this therapeutic strategy, we conducted clinical trials to evaluate the effectiveness of c-myb targetted ODNs as marrow purging agents. We have ...
In order to further explore the regulation of human c-myb gene by distal upstream element. First, our lab had found out that distal upstream DNA sequence interacts with the promoter region of c-myb gene by 4C experiment in human K562 cell. We proposed ...
Here, we found that the c-myb gene is expressed in proliferating C2C12 myoblasts and turned off in differentiating cells. Detailed analysis of c-myb RNAs revealed that the cell density is the essential factor determining c-myb expression. Both c-myb and its alternatively spliced form c-mybE9A...
Gene Name: MYB Protein Name: Transcriptional activator Myb Human Gene Id: 4602 Swiss-Prot: P10242 Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Source: Polyclonal, Rabbit Dilution: IHC: 1:100-1:300 ELISA: 1:5000 Purification: The antibody was affini...
Gene ID4602(Human) SwissProtP10242(Human) SynonymsCmyb; c-myb; c-myb_CDS; efg CategoryOthers BackgroundThe Myb family of transcription factors regulates proliferation, differentiation and apoptosis of hematopoletic cells. The avian myeloblastosis viral (v-Myb) protein is nuclear and binds to spec...
Gene ID (NCBI) 4602 RRID AB_3085249 Conjugate Unconjugated Form Liquid Purification Method Protein G purification UNIPROT ID P10242 Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Storage Conditions Store at -20°C. Stable for one year after shipment. Aliquoting is unnecess...
Gene ID (NCBI) 4602 RRID AB_3670267 Conjugate Unconjugated Form Liquid Purification Method Protein G purification UNIPROT ID P10242 Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Storage Conditions Store at -20°C. Stable for one year after shipment. Aliquoting is unnecess...
关键词c-myc；c-myb；白血病；骨髓基质细胞 中图分类号R733．7文献标识码A Expression of c-myc and c-myb Gene in Leukemic Bone Marrow Stromal Cells and Their Correlation ZHANG Ying，CHEN Rui，ZHANG Wei，LI Juan，CHEN Xuan，ZHAO Li* Central Laboratory，The First Hospital of Lanzhou University，...
In addition, the carboxyl terminal region of human c-myb was placed in an expression vector to obtain protein for the generation of antiserum, which was used to identify the human c-myb gene product. Like v-myb, this protein was found within the nucleus of leukemic cells where it was ...