Protein kinasesGenome editingC-terminusLoss-of-function mutants are fundamental resources for gene function studies. However, it is difficult to generate viable and heritable knockout mutants for essential genes. Here, we show that targeted editing of the C-terminal sequence of the embryo lethal ...
The PXDLS-binding cleft, RRT-binding cleft, and dehydrogenase domain of CtBP1 and CtBP2 compose the majority of the CtBP protein structure. Note the longer N-terminus of CtBP2, which contains an NLS that is absent from CtBP1. Also note that CtBP1 contains a PDZ domain at the C-terminu...
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Here we report that RecG co-localises with sites of DNA replication and identify conserved arginine and tryptophan residues near its C-terminus that are needed for this localisation. We establish that the extreme C-terminus, which is not resolved in the crystal structure, is vital for DNA ...
CLEC2 is a Syk-CLR that is specifically expressed in human platelets. Human CLEC2 encodes a 229–amino acid type II transmembrane protein, comprising a C-type lectin domain in the C-terminus, and a single YxxL motif (hemITAM) in the intracellular domain located at the N-terminus [60,61...
In order to analyse Dectin-1 processing at the endogenous level, we generated an antiserum against the Dectin-1 N-terminus, which specifically detects both isoforms upon overexpression (Supplementary Fig. 2a) as well as endogenously (Supplementary Fig. 2b). We compared Zymosan (Zym)-induced Dectin...
The intracellular C-terminus of the GPCR contains many serine and threonine residues whose hydroxyl (–OH) groups can be phosphorylated by GRKs (Gurevich & Gurevich, 2019). This phosphorylation leads to diminished receptor–G-protein coupling and increases the affinity of the receptor ...
描述:Recombinant Human Vascular Endothelial Growth Factor C is produced by our Mammalian expression system and the target gene encoding Phe32-Arg227 is expressed with a 6His tag at the C-terminus. Accession:P49767 中文别名:VEGF-C蛋白 来源:Human Cells ...
The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit Mol. Cell. Biol., 19 (1999), pp. 3267-3277 Google Scholar Smogorzewska et al., 2002 A. Smogorzewska, J. Karlseder, H. Holtgreve-Grez, A. Jauch, T. de Lange DNA ligase IV-dependent NHEJ of depr...
Mosthaf, Luitgard et al., C-terminus or Juxtamembrane Deletions in the Insulin Receptor Do Not Affect the Glucose-dependent Inhibition of the Tyrosine Kinase Activity, ;., vol. 227, pp. 787-791, 1995. Kellerer et al., “Mechanism of Insulin Receptor Kinase Inhibition in Non-Insulin-depen...