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In this work, we introduce hyperpolarized, 13C-labelled [1,5-13C2]Z- 4-methyl-2-oxopent-3-enedioic acid (Z-OMPD) as a probe for simulta- neous 3D imaging of renal perfusion and filtration and 2D imaging of pH in vivo within a single injection. In addition, the C1-resonance allows...
Sequence analysis was performed with Unipro UGENE v1.16.1.13 An assay with dual-labelled probes (Eurofins) was designed as described by Van Poucke et al9 to genotype the KCNJ10 c.986T4C variant in additional animals. Experimental details on the genetic analysis are given in Supplementary ...
malachius. Our phylogeny did not support the close relationship of these two morphologically similar species and the grouping of collections labelled by both names within each phylogenetic species reflects unreliable species delimitations in the traditional literatures. Both species inhabit the wood of ...
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I/R injury is also associated with neuroinflammation and pyroptosis, of which its mechanistic basis may be due to increased M1 microglia, which has been found post-injury in various organs, such as the brain [43,44], spine [45], heart [46], and retina [47]; these M1 microglia, in tu...
Specifically, pyramidal neurons in the medial prefrontal cortex (mPFC) of GluN2C knockout mice have reduced mEPSC frequency and dendritic spine density and a contrasting higher frequency of mIPSCs. In addition a greater number of perisomatic GAD67 puncta was observed suggesting a potential increase...
To evaluate the pH sensitivity of the13C-labelled carboxylic acid carbons, a titration series of thermal13C-NMR spectra in the in vivo relevant pH range (~pH 7) reveals changes of the chemical shift of both13C-labels with pH in opposite field directions (Fig.1b) relative to [13C]urea...