贺 近日,上海交通大学生命科学技术学院、微生物代谢国家重点实验室邓子新团队合作于《自然通讯》(Nature Communications)杂志上发表题为 “聚酮合酶的碳-氮键形成”(C-N bond formation by a polyketide synthase)的研究论文。该工作通过...
近日,上海交通大学生命科学技术学院、微生物代谢国家重点实验室邓子新团队合作于《自然通讯》(Nature Communications)杂志上发表题为 “聚酮合酶的碳-氮键形成”(C-N bond formation by a polyketide synthase)的研究论文。上海交大博士后王嘉良、上海佶凯星生物科技有限公司汪小杰、上海交大硕士李希希、国家蛋白质科学中心...
近日,上海交通大学生命科学技术学院、微生物代谢国家重点实验室邓子新团队合作于《自然通讯》(Nature Communications)杂志上发表题为 “聚酮合酶的碳-氮键形成”(C-N bond formation by a polyketide synthase)的研究论文。上海交大博士后王嘉良、上海佶凯星生物科技有限公司汪小杰、上海交大硕士李希希、国家蛋白... 近日...
近日,上海交通大学生命科学技术学院、微生物代谢国家重点实验室邓子新团队合作于《自然通讯》(Nature Communications)杂志上发表题为 “聚酮合酶的碳-氮键形成”(C-N bond formation by a polyketide synthase)的研究论文。上海交大博士后王嘉良、上海佶凯星生物科技有限公司汪小杰、上海交大硕士李希希、国家蛋白质科学中心...
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Polyketide synthases (PKSs) usually form C–C bonds in natural products biosynthesis. Here, the authors present cryo-EM structures of a PKS in complex with products, which provides insight into the mechanism of the unexpected C–N bond formation....
近日,上海交通大学生命科学技术学院、微生物代谢国家重点实验室邓子新团队合作于《自然通讯》(Nature Communications)杂志上发表题为 “聚酮合酶的碳-氮键形成”(C-N bond formation by a polyketide synthase)的研究论文。上海交大博士后王嘉良、上海佶凯星生物科技有限公司汪小杰、上海交大硕士李希希、国家蛋白质科学中心...
The C domain catalyzes peptide bond formation between sequential amino acids. Last, the additional thioesterase (TE) domain releases the mature peptide product via hydrolysis or cyclization3,4. Nonribosomal lipopeptides have fatty acyl chains at the N-terminus, which are introduced by a starter ...
Incubations of 1 and 4 in our lab with NaBH4 in THF lead to the formation of both 3 and 6. For the synthesis of 6 a Michael addition of a hydrogen equivalent or the action of an enoylreductase of a polyketide synthase seems possible. Current experiments by our groups directed to the ...
In 2004, a new class of polyketide antibiotics, the abyssomicins, were identified from the deep-sea sediment-derived actinomycete, Verrucosispora strain AB 18-032, collected in the sea of Japan at a depth of 289 m (Bister et al., 2004). Bioassay-guided isolation, following the inhibitory...