Both 15c and 15d downregulated c-MYC in the same cells, but this effect was largely transient because its mRNA and protein levels recovered rapidly. In contrast, the strong downregulation of MCL1 observed in vitro and in vivo only with epi-PROTACs 15a and 15c has been proposed by Wang and ...
MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation. Cell Metab. 2017, 26, 633–647.e637. [Google Scholar] [CrossRef] Vlashi, E.; Lagadec, C.; Vergnes, L.; Matsutani, T.; Masui, K.; Poulou, M.; ...
此外,影响血管新生和肿瘤细胞侵袭的他汀类药物有:西立伐他汀(cerivastatin)、 阿托伐他汀(atorvastatin)和辛伐他汀(simvastatin);影响HCV病程的有洛伐他汀(lovastatin);抑制胚胎干细胞增殖的有辛伐他汀(simvastatin);抑制Myc磷酸化和活化的有阿托伐...
Overexpression of BAFF has been shown to enhance c-myc expression and promote CLL-like disease via activation of the canonical IKK in Myc/BAFF Tg mice [156]. BAFF production by stromal support cells, such as microvascular endothelial cells, has been shown to be triggered by CD40L aberrantly ex...
while Myc expression in wild-type organoids induces HCC formation Cholangiocytes from KrasLSL-G12D, Trp53f/f mice Tumours with a high stromal component expressing CCA markers Quick model, orthotopic implantation in the liver, iCCA exclusive, stroma presence Quick model Tumour latency of 6–8 ...
(3 μM, 24 h).B-CThe protein level of MCL1 could be up-regulated by venetoclax, while down-regulated by tunicamycin (B) and sorafenib (C). The MCL1 levels of NB4 cells were further decreased by treatment with tunicamycin + venetocalx and sorafenib + venetoclax.DCombined ...
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