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Afterwards, chromatin was fragmented by sonication and incubated overnight at 4 °C with anti-c-Myc antibody (Abcam, ab32072) or IgG (Proteintech, B900610) and Protein A/G magnetic beads. After washing the complexes with low-salt and high-salt solutions in turn, purified DNA was ...
The co-expression of CFP and transthyretin in scat- tered epithelial cells of the postnatal mouse CP in Nestin-CFP mice [12] suggested that our construct was expressed in the epithelial lining of the CP (Add- itional file 3: Figure S2G). To confirm that it was c-MYC overexpression in ...
(ab32072)Anti-c-Myc antibody [Y69] - ChIP Grade an Antibody byAbcam (E1910)Dual-Luciferase® Reporter Assay System a Kit byPromega (K606)Glucose Colorimetric/Fluorometric Assay Kit a Kit byBioVision (K607)Lactate Colorimetric/Fluorometric Assay Kit ...
The following antibodies were used for western blot: c-Myc (Abcam, ab32072, 1:1000), Wnt2b (Abcam, ab178418, 1:1000), beta Catenin (Abcam, ab68183, 1:1000), E-cadherin (Abcam, ab40772, 1:1000), α-catenin (Abcam, ab51032, 1:1000), N-cadherin (Abcam, ab76011, 1:1000), ...
Soluble proteins were analyzed by immunoblotting with anti-MUC1-C (Thermo Scientific), anti-MYC (Abcam; AB32072 reactive with MYC and not MYCN or MYCL), anti-β-catenin (BD Biosciences), and anti-β-actin (Sigma) antibodies. Detection of immune complexes was achieved using horseradish ...
c-MYC IHC analysis was performed using an antibody against c-MYC (clone Y69, catalog ab32072, Abcam, Burlingame, CA, USA). ß-catenin IHC used a commercially available antibody against ß-catenin (clone CAT-5H10, Invitrogen, Camarillo, CA, USA). The staining process was performed using...
3.本发明的领域涉及作为c-myc靶向剂的取代的杂环。特别地,本发明的领域涉及取代的吡唑、嘧啶或三唑作为c-myc靶向剂,用于治疗细胞增殖性疾病和障碍,例如癌症。 4.c-myc癌基因失调并且在大多数人类癌症中起因果作用,并且c-myc抑制在多种模型中深刻影响肿瘤的生长或存活。myc是人类癌症中最常见的癌基因,在多达一半...
c-Myc was a main effector of TCF7 in PHCC cells and modulated TCF7-induced proliferation, invasion, and migration. FOS-like antigen 1 (FOSL1) was identified as a downstream target of TCF7 and was required in TCF7-induced PHCC proliferation. Triple-positive expression of TCF7, c-Myc, ...
The proto-oncogene c-Myc encodes a short-lived protein c-Myc that regulates various cellular processes including cell growth, differentiation and apoptosis. Degradation of c-Myc is catalyzed by the proteasome and requires phosphorylation of Thr-58 for ubiquitination by E3 ubiquitin ligase, Fbxw7/ ...