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Residue assignments of the variant were based on the Gangabadage9 assignment of the wild-type protein, using a nuclear overhauser effect spectroscopy (NOESY)-HSQC spectrum (120 ms mixing time) to reassign perturbed residues around the mutation site. Large chemical shift changes from the WT are ...
No entanto, num estudo prospetivo que incluiu 1360 doentes com doença coronária estável e instável (AI e EAM), o hazard ratio (HR) ajustado para EAM/morte para níveis de PCR-as acima do 1.° tercil foi de 1,8 na angina estável; 2,7 na angina instável (AI) e de apena...
All Special IssuesActive Pharmaceutical IngredientsAdvances in Drug DesignAdvances in Natural Products and Their Derivatives for Metabolic and Chronic Inflammatory Disease Therapy, 2nd EditionAdvances in Nuclear MedicineAdvances in Pharmaceutical Sciences: In Honor of Dr. Jean Jacques Vanden Eynde (JJ)Advers...
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An alteration in the balance between oxidant generation and antioxidant defenses can lead to alterations in multiple signaling pathways, with the pro-inflammatory transcription factor nuclear factor кB (NFкB) playing a central role [121]. Oxidants can activate NFкB, which triggers a signaling ...