This reaction complements ‘C–H activation’ strategies that convert inert C–H bonds into C–metal bonds prior to C–C bond formation. Instead, this reaction exploits an inverted sequence and promotes C–C bond formation prior to deprotonation. These studies provide an opportunity to develop ...
(S)C(SiMe3)CHO}] (4), and [Os3(CO)9(μ3-S){μ3-η2-(Me3Si)CCCCFc}] (5) were obtained from the reaction of FcCCSCCSiMe3 with the activated cluster Os3(CO)10(NCMe)2, as a result of S−C and C−H bond activation as well as C−C coupling reactions in the thioether...
Methods for selective C–H bond functionalization have provided chemists with versatile and powerful toolboxes for synthesis, such as the late-stage modification of a lead compound without the need for lengthy de novo synthesis. Cleavage of anC–H bond via hydrogen atom transfer (HAT) is particula...
Fig. 1: The rationale for selective C–H bond functionalization of mitragynine (MG) and 7-hydroxymitragynine (7OH). a MG is readily obtained in multigram quantities from kratom powder by extraction, hence there is an incentive to develop selective functionalization of MG and related scaffolds via...
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Intramolecular C(sp3)–H Bond Activation Reactions of Low-Valent Cobalt Complexes with Coordination Unsaturation Intramolecular C(sp3)–H bond activation reactions mediated by low-valent cobalt, both Co(I) and Co(0), have been observed in the reactions of the three-co... Z Mo,D Chen,X ...
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A new method for C–C and C–N bond formation of heteroaromatics and C(sp3)–H alkanes was developed with high regioselectivity. The reaction occurred on C8 to give 8-cylcoakylpurines by C–C bond formation only promoted by tBuOOtBu, while it occurred on the amino group to give N6-al...
A has been structurally characterized as its PMe3 adduct and is capable of effecting single and multiple C−H bond activations of hydrocarbon solvents. For example, the thermal reaction of 1 with cyclohexane leads to the formation of the 18e cyclohexenyl hydrido complex, Cp*W(NO)(η3-C6H9...
The relative sign and magnitude of the 19 F- 13 C, 1 H- 13 C, and 1 H- 19 F coupling constants are determined with facility by the skewing and separation of multibond and direct cross peaks in the 2D heteronuclear NMR spectra. The ability to obtain the coupling information potentially ...