本发明提供了结合到肿瘤相关抗原CLEC12A并结合到自然杀伤细胞上的NKG2D受体和CD16受体的多特异性结合蛋白.本发明的一个方面提供了一种蛋白质,其包含:结合NKG2D的第一抗原结合位点;结合CLEC12A的第二抗原结合位点;和抗体Fc结构域,其足以结合CD16的部分或结合CD16的第三抗原结合位点.所述抗原结合位点可以各自包含抗体...
C-type lectin domain family 12 member A (CLEC12A), also known as C-type lectin-like molecule 1 (CLL1), dendritic cell-associated lectin 2 (DCAL-2), myeloid inhibitory C-type lectin-like receptor (MICL), killer cell lectin like receptor-1 (KLRL1) and CD371, is a member of the C-...