thymidine kinase(TK) gene. In the presence of theprodrugganciclovir, TK expression kills not only the TK-transfected cells but also the nearby untransfected cells [116]. The gap junction that mediates the intercellular communication appears to be responsible for the TK-induced bystander killing [...
ARTICLE Received 26 Nov 2014 | Accepted 27 Jan 2015 | Published 30 Mar 2015 DOI: 10.1038/ncomms7410 Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing Rozanne Arulanandam1, Cory Batenchuk1, Oliver Varette1, Chadi Zakaria...
Such bystander-activated cells are important in early anti-viral defense (Maurice et al., 2021) and characteristically express NKG2D, involved in the killing of infected cells, and both IL-7 receptor (IL7R) and CD8, which are downregulated in a T cell receptor (TCR)-dependent fashion (Kaec...
CAR(NAP) T cells are CAR T cells armed with NAP, an immune activator derived fromH. pylori. Within a solid tumour, heterogeneity in antigen expression makes it difficult to eradicate all tumour cells with conventional CAR T cells. CAR(NAP) T cells secrete NAP during killing of tumour cells...
3c) and plaque assay (Fig. 3e). We next measured the levels of infection over time using MuHV-4-luc recombinant virus for live imaging of light emission centered on the thorax at days 2, 5, 7, and 9 pvi33. S. mansoni egg treatment resulted in significantly reduced levels of light ...
CD4+ T-cell death is a crucial feature of AIDS pathogenesis, but the mechanisms involved remain unclear. Here, we present in vitro findings that identify a novel process of HIV1 mediated killing of bystander CD4+ T cells, which does not require productiv
Here we investigated whether antibody recognition of shed gp120 bound to the surface CD4 of bystander cells results in ADCC-mediated killing. To this end, we developed a FACS-based assay to measure the relative killing of infected CD4 + T cells versus their uninfected counterparts by ADCC-media...
From these experiments, we observed that there is an increased bystander killing in cells deficient in cisplatin-DNA damage repair. This suggests that the level of DNA damage and DNA damage signaling could help propagate the death signal in the BE. Figure 5. Clonogenic survival in ERCC1/XPF ...
Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions. Proc. Natl. Acad Sci. USA 2004, 101, 6134–6139. [CrossRef] [PubMed] 6. Wu, D.; Li, B.; Liu, H.; Yuan, M.; Yu, M.; Tao, L.; Dong, S.; Tong, X. In vitro...