Could bystander killing contribute significantly to the antitumor activity of brentuximab vedotin given with standard first-line chemotherapy for Hodgkin lymphoma? Immunotherapy 2014;6:371-5.Brown MP, Staudacher AH. Could bystander killing contribute signifi- cantly to the antitumor activity of brentuximab...
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“The bystander effect is expected to improve the efficacy of the ADC drug by killing, in addition to the targeted cancer cells, a significant number of nearby, nontargeted cancer cells usually found within or in close proximity to malignant tumors,” Nicolaou said. Nicolaou’s lab, which speci...
1)Bystander effect旁观者效应 1.The killing effect and bystander effect of linamarase/linamarin suicide gene system on human hepatocellular carcinoma cell line HepG2 in vitro;新型自杀基因linamarase/linamarin系统对人肝癌细胞HepG2体外杀伤效应及其旁观者效应的初步观察 2.Study on mechanism of bystander eff...
There are comments on PubPeer for publication: Mitomycin C induces bystander killing in homogeneous and heterogeneous hepatoma cellular models (2009)
Cancers express antigens that are targets for specific cytotoxic T lymphocytes (CTLs)1,2. However, cancer cells are genetically unstable3. Consequently, sub-populations of cancer cells that no longer express the target antigen may escape destruction by C
memory CD8+T cells functionally resemble NK cells7. Both are capable of killing targets upon engagement of innate immunoreceptors (specifically NKG2D); however, bystander-activated memory CD8+T cells typically do not express innate inhibitory receptors that restrict killing7. In addition, both migrate...
The second step is the recognition and killing of antigen-presenting cancer cells by the activated CD8+ T cells. However, cancer cells can hide their antigens from immune cells through multiple mechanisms [70]. Bacterial peptides are prevalent among melanoma metastasis [71]. They can be ...
DSB-inducing activity (of conditioned medium collected from the irradiated culture) D-NMMA: NG-methyl-D-arginine DSBs: DNA double strand breaks ESR: electron spin resonance γ-H2AX: phosphorylated form of H2AX protein L-NMMA: NG-methyl-L-arginine L-NNA: Nω-nitro-L-arginine 7-Ni:...
Importantly, this innate-like recognition of target cells does not appear to be nearly as efficient as T cell receptor (TCR)- mediated target cell killing7, but the consequences for the host are still significant given the large number of memory T cells and their ability to produce other ...