but its tight regulation and strong induction during the very late stages of lytic infection supports a role in virus particle assembly, possibly by dissociating transcribing RNAP from viral genomes. The strong and stable interactions between RIP and the RNAP clamp and rudder make RIP a lethal pr...
Zα domains fold into a compact α+β structure called a winged helix-turn-helix (HTH) domain with a small three-helical bundle capped with a short two-stranded antiparallel β sheet (α1-α2-α3-β1-β2) (Figure 2). The crystal structure has been determined of human ADAR1 Zα doma...
Furthermore, the NMR structure of the Nrd1-RRM showed a largely unstructured helix-loop bundle lying C-terminally to a classical RRM fold38. We expressed Seb1-RRM388–540 and crystallized the purified domain (Supplementary Fig. 5b-e), yielding diffraction data up to 1.0 Å. The structure...
And the results showed that the colony number of miR-494 overexpressed cells was lower than that of the control group (Figure 2b). Considering tumor invasion and metastasis are common features of the most aggressive and lethal tumors, we detected the effects of miR-494 overexpression on ...