Sun W, Yang S, Shen W et al: Identification of DeltaEF1 as a novel target that negatively regulated by LMO2 in T cell leukemia. Eur J Haematol, 2010; 85(6): 508-19Sun, W. et al. Identification of DeltaEF1 as a novel target that negatively regulated by LMO2 in T cell leukemia....
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Moreover, we found, that targeting of LMO2 deacetylation by NAMPT/SIRT2 inhibition may be a potential novel therapy for LMO2-related T-ALL.BloodTatsuya Morishima MD PhDChristian LindnerBenedikt OswaldMarcus HartmannMasoud Nasri MScLothar KanzPatrick MüllerKarl WelteJulia Skokowa...
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The proto-oncogene LIM-domain only 2 (lmo2) was traditionally considered to be a pivotal transcriptional regulator in hematopoiesis and leukemia. Recently, the cytosolic localization of LMO2 was revealed in multiple epithelial tissues and a variety of so
Background: MYCN and LMO1 amplification are commonly observed in neuroblastoma (NB), which was often accompanied by genetic loss of let-7 microRNA (miRNA). Fibroblast growth factor (FGF) was found to regulate let-7 miRNA expression via FGF receptor substrate 2 (FRS2), which then activates ...
By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails. Already on GitHub? Sign in to your account 1.2.0 #6 Merged ayuanlmo merged 36 commits into main from dev Nov 30, 2023 Merged 1.2.0 ...
Ectopic expression of LIM-only protein 2 (LMO2) in T-cells, as a result of chromosomal translocations or retroviral insertion, plays an important role in the onset of T-cell leukemias. Two transcripts of LMO2 gene (LMO2-a and LMO2-b) have been reported t