To analyze the glycolytic capacity of the cells, the glucose consumption from the cell media was measured. A decrease in glucose consumption was observed for the cell lines H1299 and H460 CDDP-resistant compared to their parental versions, but no differences were detected between parental and ...
In this study, however, it is the mass balance and the requirement of maintaining flux balance is sufficient to regulate the flux into other neighboring anabolic pathways. Conversely, other mechanisms have been proposed that lead to increased serine synthesis by accumulation of glycolytic intermediates...
For example, HIF-1 induces the expression of glycolytic genes. It is presumed that increased glycolysis is necessary to produce energy when low oxygen will not support oxidative phosphorylation at the mitochondria. However, we find that while HIF-1 stimulates glycolysis, it also actively represses ...
cellular respiration d. Calvin cycle Where is the energy stored and released using ATP? After fermentation, which molecule retains most of the chemical energy of glucose? Where is the glucose stored in a plant like a beet? When do skeletal muscle cells use only the glycolytic pathway...
Furthermore, glycolytic changes cause mitochondrial dysfunction, manifesting the influence of oxidative stress [11]. ROS is released as by-products in aerobic metabolism, which is usually associated with oxidative metabolism as well as increasingly appreciated functions in the pathophysiology of renal ...
Further, lactate production by glycolytic cancer cells can induce the upregulation of HIF-1α in TAMs to enhance the expression of glycolytic genes and M2-like state [34]. Therefore, glycolysis is an important metabolic process sustaining the functional phenotype of TAMs. Z eng et al. J ...
The ECAR reflects aerobic glycolysis flux while the OCR is indicative of the state of mitochondrial oxidative respiration [28]. Taken together, our findings showed that HPV16/18 E6/E7 enhances the proliferative, metastatic, and aerobic glycolytic capacity of CC cells....
Therefore, during vinification, these strains could undergo an increase in glycerol levels at the expense of glycolytic flux, reducing ethanol without increasing volatile acidity, as pyruvate is being pushed towards α-ketoglutarate synthesis, consuming acetyl-CoA in the process (Fig. 3, Additional ...
[72]. The promoters most commonly employed inS. cerevisiaeare strong glycolytic promoters and conditionally inducible promoters. Strong glycolytic promoters, such aspTDH3,pPGK1,pTPI1, andpADH1, have high levels of transcription. Conditionally inducible promoters, such aspGAL1,pGAL7,pGAL10,pPHO5, ...
Furthermore, BMDM–HG-exo induced cell proliferation and reprogrammed energy metabolism by increasing glycolytic activity. Lastly, profiling microRNA in BMDM–HG-exo and plasma EVs from diabetic subjects with advanced atherosclerosis converged on miR-486-5p as commonly enriched and recognized in ...