Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin. Chembiochem 2007;8:283-288.288 [PubMed: 17206729]. Describes the bifunctional roles of the oxidases and the aminotransferases in the neomycin and butirosin pathways.Huang, F. et al. Elaboration of neosamine rings in ...
Comparison with the neomycin biosynthetic gene cluster [17] shows that btrG, btrH, btrI, btrJ, btrK, and btrO are unique to the butirosin cluster (Figure 2), suggesting that some or all of these genes relate to the synthesis and transfer of AHBA, which is not present in neomycin. ...
2.14.3.5.34,5-Disubstituted 2-DOS aminoglycoside—Biosynthesis of 2-deoxystreptamine (DOS) in butirosin Most FDA-approved aminoglycosides, like gentamicin, kanamycin, neomycin, and the recently approved plazomicin, possess a common glucose-6-phosphate-derived 2-deoxystreptamine (2-DOS,145) aminocy...