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1. Identify a model PROTAC that can potentially demonstrate activity based on knowledge in PROTAC design or in vitro binding studies. 2. Perform a time course study with 2–3 doses of the model PROTAC based on affinities of the ligands selected. 3. Monitor ubiquitination and degradation ...
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For example, studies have shown that American adults who do not self-identify as white report better mental and physical health if they think others perceive them as white (11, 12). The benefit of using multiple measures of race and ancestry also extends to genetic studies. In a study of ...