How this conformational cycle contributes to microtubule growing, shrinking, and switching remains unknown. Here, we report that a buried mutation in αβ-tubulin yields microtubules with dramatically reduced shrinking rate and catastrophe frequency. The mutation causes these effects by suppressing a ...
(Ironically, this approach recalled the management consulting practice of process mapping, which uses a linear diagram to detail parts of a process in order to identify inefficiencies and bottlenecks. But it also has similarities to the storylining process used to map out plays, TV shows and film...
1. Define the N "diagonal pattern matrices", labelled matrix 0 through N-1 and the "pattern sequence matrix" that will be used 2. In the first scheduling phase, which lasts from time slot 0 to N-1, use diagonal pattern matrix 0 and the pattern sequence matrix as was described in the...
1973; Ackerman and Bauer1976) as a vehicle for CSR, and corporate social performance (CSP). One of the best-known writers to make this distinction was Sethi (1975, p.60) who discussed “dimensions of corporate social performance”, focusing on the distinguishable corporate ...
four instructions has two destination operands, and even if less than all of the destination operands are copied to GPRs 32 during the particular cycle. FIG. 11 is a block diagram of an alternative embodiment of rename buffers 34 in which the "writeback entries" are stored in a buffer 110...
detail so that the proteins to be broken down at any given moment are given a molecular label, a ‘kiss of death’, to be dramatic. The labelled proteins are then fed into the cells’ “waste disposers”, the so called proteasomes, where they are chopped into small pieces and destroyed...
I’ve seen it happen many times, but it never ceases to sadden me. An organization starts off with a clear vision and an impervious commitment to excellence, but as it grows, the vision blurs and excellence gets diluted through a series of compromises. Software companies are often founded ...
During each of the steps in the Oneflow application, the data is enriched, the cycle progresses but nothing is locked down until it is required – i.e. when a legal contract is signed by two parties. Oneflow Workflow for Contract Handling When I got my first typewriter with correction tape...
and has the waveform labelled MC in FIG. 3. To maintain precision clock timings, MC preferably is a differential signal; that is, each line 1132 is actually implemented as a pair of physical conductors carrying complementary voltages. However, either single-ended or differential signals are useful...
that the folding and unfolding of proteins is associated with a whole range of cellular processes from the trafficking of molecules to specific organelles to the regulation of the cell cycle and the immune response. Such observations led to the inevitable conclusion that the failure to fold correctl...