Route of Administration (Grade): Oral Pharmacopoeia Reference: Conforms to Japanese Pharmaceutical Excipients. All components meet USP-NF, JP, EP. US DMF Type IV filed. Technical Specifications: Not Available ASKUS Uploadyour Marketing & Sales content Roquette Upload your Marketing & Sales content...
IV or IM administration may be used in patients unable to take oral medication or who have impaired GI absorption; resume oral administration as soon as possible.Rate of AdministrationFor direct IV injection, administer slowly over a period of 1–2 minutes....
The pharmacokinetic and pharmacodynamic data support the conclusion that bumetanide is galenically available from the tablet dosage form and that comparable cumulative diuretic activity is obtained, regardless of the route and mode of administration....
These results indicated the possibilities of the rectal route of administration of drugs which are weak organic acids and show low or variable bioavailability following oral administration. 展开 关键词: BUMETANIDE BIOAVAILABILITY SUPPOSITORY RECTAL ADMINISTRATION CITRIC ACID TARTARIC ACID ...
administration. Given by the intramuscular (i.m.) route, bumetanide was rapidly absorbed; bioavailability was 70–80%. i.m. administration of bumetanide prolonged its plasma half-life (11–27 min) and enhanced and prolonged its diuretic effect....