Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cellsdoi:10.1038/cmi.2015.61BcellsCD180IFN-αSLEA hallmark of systemic lupus erythematosus (SLE) is the consistent production of various auto-antibodies by auto-reactive B cells. Interferon-α (IFN-α) ...
Augmented TLR9-induced Btk activation in PIR-B鈥揹eficient B-1 cells provokes excessive autoantibody production and autoimmunity Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity. J Exp Med. 2009;206(9):... T Kubo,Y Uchi...
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据悉,SN1011是一款第三代可逆共价BTK抑制剂,其设计在长期治疗系统性红斑狼疮、寻常型天疱疮、多发性硬化症、类风湿关节炎及其他免疫性疾病方面具备更高选择性、更卓越疗效及更高安全性。在作用机理、亲和性、靶向选择性及安全性方面,SN1011与目前市场现有的BTK抑制剂(如依鲁替尼)等具有差异性优势。 值得一提的是,...
Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cellsB cells, CD180, IFN-α, SLEA hallmark of systemic lupus erythematosus (SLE) is the consistent production of various auto-antibodies by auto-reactive B cells. Interferon-α (IFN-α) signaling is ...
(GC ) B 房间.尤其是, CD180 的结扎显著地禁止了 IFN-α信号变换器的导致的 phosphorylation 和抄写 2 的使活跃之物(STAT-2 ) 和以在 vitro 的一种 Lyn-PI3K-BTK-dependent 方式的刺激 IFN 的基因(ISG ) 的表示.而且, CD180 的结扎能也禁止 IFN-α在在 vivo 的 B 房间的导致的 ISG 表示.而且,像...