Full size image Figure5shows the details of one of the transition trajectories from the BTK-ASH ensemble starting from the 3OCT crystal structure with an unfolded A-loop and DFGoutstate (Supplementary Movie 2). Within the trajectory, the A-loop first folds into the ATP binding site, forming ...
Full size image Simultaneous knockdown of Etk and Btk inhibits prostate cancer cell growth Etk knockdown has been reported to slow down prostate cancer cell growth. A similar result was observed in PC3 cells with Etk knockdown (Figure 2a). To explore the role of Btk in prostate cancer cell gr...
Movie 2. Btk29AEP homozygous mutant embryo expressing DE-Cadherin-GFP monitored from middle stage 12 (8 h 30 min AEL) till stage 13 (for approximately 2 h). The more distal cells do not complete invagination even after 120 min from the beginning of the imaging. Zoom in the posterior regi...