A label-free quantitative proteomic strategy was carried out to identify up- and downregulated proteins upon neddylation inhibition with MLN4924 (a small-molecule inhibitor of the neddylation pathway) in HepG2 cells (Fig.1a). A total of 8539 proteins were detected, among which 384 proteins were ...
The invention also envisages methods of identifying an inhibitor, pro-drug or drug capable of modulating the activity of a peptide or protein of the invention, a diagnostic kit for detection of a single nucleotide polymorphism and gene therapies on the basis of gene variants detected with the ...
The invention also envisages methods of identifying an inhibitor, pro-drug or drug capable of modulating the activity of a peptide or protein of the invention, a diagnostic kit for detection of a single nucleotide polymorphism and gene therapies on the basis of gene variants detected with the ...