在体外研究中,为了模拟2型糖尿病所致的器官损伤,除在细胞培养基中添加高浓度的葡萄糖外,通常需要添加高浓度的棕榈酸钠(Palmitic acid)和/或油酸钠(sodium oleate),这是因为软脂酸是存在于动物、植物及微生物中最常见的饱和脂肪酸。 正常情况下,人体血液中软脂酸的浓度均值约为100umol/L,肥胖和2型糖尿病情况下血...
Palmitic acid (PA) and its solvent (vehicle) were purchased from Kunchuang Biotechnology (Xi’an, Shanxi, China), in which PA was coupled to FA-free bovine serum albumin (BSA) in a ratio of 2mM PA:3% BSA 2)High-fat diet impairs ferroptosis and promotes cancer invasiveness via down regul...
In an obese mouse model, a high-fat diet (HFD) significantly increased the expression levels of APP and BACE1 as well as the AD pathology in the mouse brain. We further found that PA conjugated with bovine serum albumin (PA-BSA) increased the expression of APP and BACE1 and the ...
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