溴结构域和植物同源域PHD含指蛋白1(Brpf1)是一种支架蛋白,是与单核细胞白血病锌指蛋白(MOZ 或 KAT6A)、单核细胞白血病锌MOZ 相关因子(MORF 或 KAT6B)或与起源识别复合物亚基 1(ORC1(HBO1 或 KAT7))结合的跨膜丝氨酸蛋白酶 11DHAT 和2个小的非催化蛋白、生长抑制剂 5 (ING5) 或 ING4 和 MYST/Esa1...
brpf1还含有通常存在于染色质相关因子的其他结构域,包括1个双植物同源结构域(phd结构域)和锌指结构域(znf结构域)组件(pzp)以及1个chromo/tudor相关的pro-trp-trp-pro(pwwp)结构域。brpf1与单核细胞白血病锌指蛋白(moz,也称为kat6a或myst3)、生长抑制因子(ing5)和esa1相关因子(heaf6)同源物形成1个四聚体复合...
The three histone acetyltransferases are MOZ, MORF, and HBO1, which are also known as lysine acetyltransferase 6A (KAT6A), KAT6B, and KAT7, respectively. The MORF gene is mutated in four neurodevelopmental disorders sharing the characteristic of intellectual disability and frequently displaying call...
Here, by interrogating CRISPR-Cas9 loss-of-function genetic screen data, we identified a list of genes essential for metastatic OC, including several well-known oncogenes (PAX8,CCNE1,WWTR1,WT1,KAT6A,MECOM, andSOX17) and others whose roles in OC have not yet been explored. Protein-protein ...
The N-terminal EPC-like motif interacts with MOZ (monocytic leukemia zinc finger protein; also known as KAT6A and MYST3) and MORF (MOZ-related factor; also known as KAT6B and MYST4), whereas the C-terminal motif associates with ING5 (inhibitor of growth 5) and EAF6 (homolog of yeast...
In addition, it binds to the acetyltransferases MOZ, MORF, and HBO1 (also known as KAT6A, KAT6B, and KAT7, respectively) to promote complex formation, restrict substrate specificity, and enhance enzymatic activity. We have recently showed that ablation of the mouse Brpf1 gene causes embryonic...
溴结构域和植物同源域PHD含指蛋白1(Brpf1)是一种支架蛋白,是与单核细胞白血病锌指蛋白(MOZ 或 KAT6A)、单核细胞白血病锌MOZ 相关因子(MORF 或 KAT6B)或与起源识别复合物亚基 1(ORC1(HBO1 或 KAT7))结合的跨膜丝氨酸蛋白酶 11DHAT 和2个小的非催化蛋白、生长抑制剂 5 (ING5) 或 ING4 和 MYST/Esa1...