Mechanism of Toxicity Bromobenzene is believed to be relatively inert, requiring metabolic activation to express toxicity to the liver and the kidney. Liver toxicity is believed to result from activation of bromobenzene to a reactive epoxide by the cytochrome P450 system. The reactive epoxides are pri...
MechanismThe hydroxycarbonylation of bromobenzene has been explored in a biphasic medium. Water-soluble [Pd(TPPTS) 3 ] (TPPTS=sodium salt of tris(3-sulphophenyl) phosphine) catalyses selectively this carbonylation reaction into benzoic acid. This complex is maintained intact in the presence of an...
In the presence of stoichiometric amounts of carbon dioxide and catalytic amounts of Ni II (dppe)Cl 2 , electrolysis of bromobenzene affords good yields of benzoic acid, with only traces ( < 0.2%) of biphenyl. The mechanism of the nickel-catalyzed electrocarboxylation is shown to proceed ...
The structure-directing activity of XB-donor species was used, for instance, in the haloform-promoted synthesis of succinic acid/caffeine cocrystals,204 or in the realization of a four-component/one-pot mechanochemical reaction for the formation of a MOF.205 The possibility to manipulate or ...