In this review, our focus is less on deciphering TXNIP’s prognostic impact but more on the role of TXNIP within the tumor microenvironment (TME), including both tumor cells and host cells, and its impact on different cancer hallmarks. Led by the literature, we pay particular attention to th...
- 《Journal of Rheumatology》 被引量: 3发表: 2017年 Effect of the extended dosing interval of anti-TNF-α NANOBODY? compound ozoralizumab in patients with low disease activity rheumatoid arthritis Objectives: This article aims to evaluate the effect of the extended dosing interval on the ...
Our previous survey on first-in-human trials (FIHT) of monoclonal antibodies (mAbs) showed that, due to their limited toxicity, the recommended phase II dose (RP2D) was only tentatively defined. We identified, by MEDLINE search, articles on single-agent
Impact of the WHO classification on the distinction between MDS and AML In order to see whether we could validate the WHO classification in patients treated with azacitidine front-line, we compared baseline and treatment characteristics, as well as the occurrence of treatment-emergent AEs (TEAEs),...
Screening for Mycobacterium tuberculosis prior to anti-TNF therapy— an audit of impact of the British Thoracic Society guidelines on rheumatology practice in an area of low Mycobacterium tuberculosis prevalence - Pradeep, Gaffney - 2009 () Citation Context ...be considered. To our knowledge, this ...
An earlier study of the rheumatoid arthritis cohort within the British Society for Rheumatology Biologics Register also found that the likelihood of recurrent discontinuation due to AE with the second biologic therapy was increased by more than 2-fold if the first biologic therapy was discontinued ...
In 2010, the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR) jointly released new classification criteria for RA to assist rheumatologists with the diagnosis of newly-presenting patients.21This assesses joint involvement, autoantibody status, acute-phase reactant...
Middle-aged obese adults are at substantially elevated risk of oesophageal adenocarcinoma. It is unclear whether this risk originates earlier in life. We assessed associations between childhood body mass index (BMI) and height—measured annually between
The aim of this report was to assess the safety of SDZ-ADL compared with conventional systemic therapies from the BADBIR. As secondary outcomes, this study assessed the real-world effectiveness and the impact on QoL using the Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality...
Apart from high-risk scenarios such as the presence of highly penetrant genetic mutations, breast screening typically comprises mammography or tomosynthesis strategies defined by age. However, age-based screening ignores the range of breast cancer risks