油菜素甾醇 (Brassinosteroids, BR )是一种重要的植物激素，对植物的生长发育具有重要的作用.BRI1 ( protein brassinosteroid insensitive 1 )是BR 的受体蛋白，定位在细胞膜上，在BR 信号被胞外结构感知到 以后，胞内部分的激酶活性被启动，从而导致抑制因子BKI1(BRI1 kinase inhibitor 1 )脱离BRI1, 随后...
油菜素甾醇(Brassinosteroids,BR)是一种重要的植物激素,对植物的生长发育具有重要的作用.BRI1(protein brassinosteroid insensitive 1)是BR的受体蛋白,定位在细胞膜上,在BR信号被胞外结构感知到以后,胞内部分的激酶活性被启动,从而导致抑制因子BKI1(BRI1 kinase inhibitor 1)脱离BRI1,随后通过一系列的激酶和磷酸酶的...
The plasma membrane proteins BRI1-associated receptor kinase 1 (BAK1)8, 9, BR-signaling kinase 1 (BSK1)10, and BRI1 kinase inhibitor 1 (BKI1)11 are involved in BR signaling by associating with BRI1. BRI1 is localized not only to plasma membranes but also to endosomes12. The ...
Transphosphorylation between BRI1 and BAK1 activates BRI1 and causes the dissociation of BRI1 kinase inhibitor (BKI1) (Wang and Chory, 2006), increasing the affinity between the kinase domains of BRI1 and BAK1 and further stabilizing the receptor/co-receptor complex (Li et al., 2002, Nam ...
BR signaling is monitored by the plasma membrane (PM)-bound receptor BRASSINOSTEROID INSENSITIVE1 (BRI1), a leucine-rich repeat (LRR) receptor-like kinase (RLK) (Belkhadir & Jaillais, 2015). Binding of BRs to the extracellular domain of BRI1 initiates an intracellular signal cascade response ...
In the absence of BRs, the cytosolic kinase domain (KD) of BRI1 is inhibited by its auto-inhibitory carboxyl terminus, as well as by interacting with an inhibitor protein, BRI1 kinase inhibitor 1 (BKI1). How BR binding to the extracellular domain of BRI1 leads to activation of the KD ...
Brassinosteroids regulate plant growth and development through a protein complex that includes the leucine-rich repeat receptor-like protein kinase (LRR-RLK) brassinosteroid-insensitive 1 (BRI1). Activation tagging was used to identify a dominant genetic suppressor of bri1, bak1-1D (bri1-associated ...
PUB30 specifically interacted with BRI1 kinase inhibitor 1 (BKI1), a regulator playing dual roles in brassinosteroids signaling, in vitro and in vivo. We found that BKI1 protein was ubiquitinated and degraded by the 26S proteasome. The degradation of BKI1 was slowed down in the pub30-1 ...
In the absence of BRs, the cytosolic kinase domain (KD) of BRI1 is inhibited by its auto-inhibitory carboxyl terminus, as well as by interacting with an inhibitor protein, BRI1 kinase inhibitor 1 (BKI1). How BR binding to the extracellular domain of BRI1 leads to activation of the KD ...
We propose a model in which heterodimerisation of the BRI1 and SERK ectodomains brings their cytoplasmic kinase domains in a catalytically competent arrangement, an interaction that can be modulated by the BRI1 inhibitor protein BKI1.Bojar, Daniel...