for seminoma and is present in most advanced seminomas. In general tumor marker levels will vary depending on the histologic cell type and stage of disease as seen inTable 1. When elevated initially serum tumor markers also have utility after orchiectomy and chemotherapy for staging and to surv...
little response was seen. The patient subsequently underwent a right mastectomy and axillary clearance. Pathology confirmed a residual pure metaplastic SCC with therapy effect seen and a single nodal involvement. Post-operative staging was ypT3 ypN1mi (yp:...
humanized 7C2 (hu7C2), that binds subdomain I of the HER2 ECD, linked to a modified PBD (pyrrolobenzodiazepine) dimer, PBD-monoamide, via a hindered disulfide linker conjugated
Tumour (T) Stage, ER IHC status, Lymph node (LN) status at diagnosis), genomic (HRD Score, PIK3CA, TP53 somatic mutation status, Coding TMB (per 45.5 Mb), chromosomal instability (CIN)) and digital pathology (lymphocyte density) feature data generated as part of the Sammut et al....
Various clinical trials have demonstrated that treatment response, including tumor shrinkage, leads to substantial downstaging of disease which in turn allows for increased use of more limited surgery [1]. In such cases, breast conservation strategies such as lumpectomies and radiotherapy can be used...
The use of image fusion, which combines available imaging techniques, can provide a three-dimensional model that allows effective staging and pre-operative planning, resulting in better surgical outcomes, reduced complications, and improved quality of life for patients. The benefits of a 3D model ...
Orel SG, Schnall MD, Powell CM et al (1995) Staging of suspected breast cancer: effect of MR imaging and MR-guided biopsy. Radiology 196:115–122 PubMed CAS Google Scholar Mumtaz H, Hall-Craggs MA, Davidson T et al (1997) Staging of symptomatic primary breast cancer with MR imaging....
we also investigated the relationship between image-based phenotypes and molecular subtypes within each lesion size strata based on TNM staging criteria, in which the data set was divided into three size groups based on effective diameters:⩽2 cm (T1); >2 to⩽5 cm (T2); or >5 ...
all 5 patients had unresolved sequelae from some of these toxicities at the time of discontinuation from study follow-up. Supplementary Fig.15depicts rash and pulmonary findings and outlines the time course of AEs in a patient who was treated at 4.0 mg/kg for 3 cycles. Two patients assigned...
81Other disadvantages of FSA are the prolonged duration of operation time and the requirement of a relatively large part of the specimen, which compromises definitive evaluation by the pathologist for histological aspects and tumor staging. In conclusion, although FSA is a relatively safe and cost-...