OBJECTIVE: To evaluate variations in the surgical practice of breast reduction mammoplasty among women >15 years of age (approximately 6.4 million population in 2008) over a 17-year period in Ontario. METHOD: A population-based, cross-sectional time series analysis was conducted to examine ...
(Chung); Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada (Andrulis); Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada (Andrulis); Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia ...
Mouse mammary tumour D2.0 R and D2A1 cells were derived from spontaneous hyperplastic alveolar nodules13,36 and provided by Ann Chambers (London Cancer Center, London, Ontario, Canada). MDA-MB-231 and MCF7 cells were obtained from American Type Culture Collection (ATCC, HTB-26 and HTB-22...
These observations must be interpreted with caution given that the molecular subtype of ER+ BC is a major confounder in all these analyses. With the introduction of PAM-50 assays in the last decade, ER-positive cancers have been divided into luminal A and luminal B tumors—the latter character...
The 13th St Gallen International Breast Cancer Conference (2013) Expert Panel reviewed and endorsed substantial new evidence on aspects of the local and regional therapies for early breast cancer, supporting less extensive surgery to the axilla and shorter durations of radiation therapy. It refined its...
(high priority intervention), tier 2 (intermediate priority) and tier 3 (low priority)—informed by the Ontario Health Cancer Care Ontario framework of resource-prioritisation and by the ESMO Magnitude of Clinical Benefit Scale (MCBS), apublic healthtool intended to support the uptake of medical ...
Jacqueline was adopted from China at five years of age. She had been abandoned at the age of 18 months at which time she had a life threatening congenital heart defect. After abandonment, she lived in an orphanage for 2.5 years before heart surgery was performed, involving six weeks hospitali...
Association between waiting time for radiotherapy after surgery for early-stage breast cancer and survival outcomes in Ontario: a population-based outcomes studydoi:10.3747/CO.27.5629M J RaphaelR SaskinS SinghMultidisciplinary Digital Publishing Institute...
In some cases, PDT may also play the role of an alternative to NAT prior to surgery. Both offer the advantages of assessing tumor response in vivo using MRI, which may allow more effective use of conservative surgical procedures. PDT can also stimulate an anti-tumor immune response. As with...
The 123 normal breast tissue is a cohort of expression data from normal breasts biopsy (n ¼ 74), reduction plastic surgery (n ¼ 37) and adjacent normal (n ¼ 12) (adjacent to tumour). Correlations between the two most likely causative SNPs (rs4442975 and rs6721996) and expression...