High mammographic density is an independent risk factor for breast cancer by poorly understood molecular mechanisms. Women with dense breasts often undergo conventional magnetic resonance imaging (MRI) despite its limited specificity, which may be increa
D. & Jemal, A. Cancer Statistics, 2017. CA Cancer J Clin 67, 7–30, https://doi.org/10.3322/caac.21387 (2017). Article Google Scholar Mohamed, A. A. et al. A deep learning method for classifying mammographic breast density categories. Med Phys 45, 314–321, https://doi.org/...
The density distributions of the BI-RADS categories measured with a publicly available software tool show that: category A dominates up to 11% with the probability P0.90 to have such density; category B dominates in the interval between 11 and 17% with P0.25 to have a density within this ...
2, Additional File 1: Table S6) and was enriched for two functional categories in DAVID: ribosomal proteins and extracellular matrix components. Insulin-like growth factor-binding protein 7 (IGFBP7) was the only gene encoding a growth factor-related protein in this gene set, and there were no...
For percentage density measured using prediagnostic mammograms, combined relative risks of incident breast cancer in the general population were 1.79 (95% confidence interval, 1.48-2.16), 2.11 (1.70-2.63), 2.92 (2.49-3.42), and 4.64 (3.64-5.91) for categories 5% to 24%, 25% to 49%, 50%...
(Corning, China) at a density of 105 cells per well and incubated at 37 °C for 24 h. Free-MDA-MB-231 cells as the control group, liposomes with CO co-incubation with MDA-MB-231 cells as the positive group, liposomes without CO co-incubation with MDA-MB-231 cells as the negative ...
BI-RADS identify 4 categories of MD in keeping with the masking effect of fibroglandular tissue, as following: A (almost entirely fat), B (scattered areas of fibroglandular density), C (heterogeneously dense), and D (extremely dense). Multivariable logistic regression was used to assess the ...
The 5–10% of patients who were positive for HER-2 or EGFR, or who were p53 positive, may not have been of the classic ILC subtype but possibly a variant, such as those found in the pleomorphic or mixed ILC–IDC categories. ILC subtypes have been reported to have different biologic ...
A study of 58,322 fibroadenoma patients with 25.3 years of follow-up proved that biopsy-confirmed fibroadenomas are a risk factor for breast cancer23. Surprisingly, our data found that endocrine resistance pathways, which could be divided into 3 functional categories, ERBB2, BCL2, and CCND1, ...
For the interpretability of the DL models, various feature attribution methods have been proposed in three categories38: gradient-based approaches (e.g., Grad-CAM and Layer-wise relevance propagation), perturbation-based approaches, and surrogate models (e.g. LIME and SHAP). For example, as ...