High mammographic density is an independent risk factor for breast cancer by poorly understood molecular mechanisms. Women with dense breasts often undergo conventional magnetic resonance imaging (MRI) despite its limited specificity, which may be increa
For percentage density measured using prediagnostic mammograms, combined relative risks of incident breast cancer in the general population were 1.79 (95% confidence interval, 1.48-2.16), 2.11 (1.70-2.63), 2.92 (2.49-3.42), and 4.64 (3.64-5.91) for categories 5% to 24%, 25% to 49%, 50%...
2, Additional File 1: Table S6) and was enriched for two functional categories in DAVID: ribosomal proteins and extracellular matrix components. Insulin-like growth factor-binding protein 7 (IGFBP7) was the only gene encoding a growth factor-related protein in this gene set, and there were no...
Total DNA of fibroadenoma tissues (Tt), fibroadenoma organoids (To), and matched peripheral blood mononuclear cells (PBMCs) were extracted using a QIAwave DNA Blood & Tissue Kit (Cat. No. 69556). Total DNA was qualified and quantified using a NanoDrop and Agilent 2100 bioanalyzer (Thermo Fis...
Mammograms were reviewed centrally by seven reviewers using Breast Imaging Reporting and Data System categories converted to numeric values. The mean mammographic densities for Caucasian, African American, and Latina patients were compared using a two-way analysis of covariance. The mean values for each...
The purpose of this study was to evaluate the performance of an algorithm used to measure the volumetric breast density (VBD) from digital mammograms. The algorithm is based on the calibration of the detector signal versus the thickness and composition of breast-equivalent phantoms. The baseline er...
The 16 prognostic genes are broken down into five categories: proliferation, invasion, HER2, estrogen and 'other'. The likelihood of breast cancer relapse in patients was based on a recurrence score (RS) algorithm constructed and tested on a cohort of 668 patient samples. The higher the RS, ...
The B-categories are also recommended to be used among women with symptomatic breast lesions [1]. The B-categories are not designed to give a definitive diagnosis, although it is possible in the majority of cases. Table 1 Reporting Categories of Needle Biopsies [2] Full size table The ...
explored the possibility of selection bias by obesity status (survivor bias), where obese women, who did not develop breast cancer by cohort entry were less susceptible, by testing an interaction term between exposure and age at entry after splitting the timescale into refined age categories. For...
categories as a proxy for menopausal status in all unique patients (n = 249). The Shapiro-Wilk test was used to assess departure from the normality assumption. Relative area of adipose tissue was compared between age categories using the non-parametric Mann-WhitneyUtest and the Kruskal-...