Courtney R (2015) The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General, 2014Us Department of Health and Human Services Atlanta, GA: PB - Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease ...
A comprehensive molecular analysis of HM tumors was performed as following: whole-exome sequencing (WES,n = 134) to define the somatic mutation landscape, messenger RNA (mRNA) high-throughput microarray profiling (n = 109) to evaluate molecular intrinsic subtypes and gene expression portra...
chemokines, and other tumor-promoting factors in the TME. The tumor-stromal cell interaction induces non-cancerous cells to acquire new tumor-promoting phenotypes, increasing tumor progression, multidrug resistance, distant metastasis, and immune suppression [3]. Studies using patient specimens have also...
Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA Paloma Cejas, Xintao Qiu, Nikolas Kesten, Alba Font-Tello, Klothilda Lim, Raga Vadhi, Len Taing, Clifford A. Meyer, Ji-Heui Seo, Matthew L. Freedman, Myles Brown & Henry W. Long Translational Oncology...
The prescription dose for both CRT and IMRT plans was 45 Gy, 1.8 Gy/fraction, prescribed to the isocenter, which was placed near the center of the breast. IMRT plans provided significantly better coverage of the left breast than the CRT plans (p = 0.03). Although the dose heterogeneity ...
This relation can be mathematically defined by the ratio of , where W is the maximum distance between a point within a cluster and its center, and B is the minimum distance between two cluster centers. In our implementation, we partition the space of k and σ into fixed intervals, perform...
Department of PathologyKeck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA, 90033, USA Michael F Press Department of Pathology, St.-Vincentius-Kliniken, Südenstr. 37, 76137, Karlsruhe, Germany Arno Dimmler Department...
Interestingly, the outer versus inner cells of AIGs were further assessed, and while cells on the periphery of clusters were inherently more inactive than cells within the center of the cluster, they were also more readily inactivated by treatment with Rac1 inhibition than cells on the inside (...
Obstetrics and Gynecology, University Medical Center Schleswig-Holstein, Luebeck, Germany Achim Rody Appendix Appendix 1.1.1 A Brief Comparison of Murine and Human Breast Differences between human and murine breasts include the following: (1) The mouse has a well-defined “fat pad” stroma into ...
Black women across the African diaspora experience more aggressive breast cancer with higher mortality rates than white women of European ancestry. Although inter-ethnic germline variation is known, differential somatic evolution has not been investigate